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Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization
Purpose: Glaucoma is the primary cause of permanent vision loss worldwide. However, the...
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Quality of Life and Primary Open-Angle Glaucoma in the Ocular Hypertension Treatment Study
Importance: If preperimetric glaucoma reduces patient-reported vision-related quality of life...
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Fatal beauty: which cosmetics are your glaucoma patients using?
Colorism refers to the difference in social treatment between light-skinned and dark-skinned...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Cerebrospinal fluid exchange in the optic nerve in normal-tension glaucoma
Author(s): Killer HE, Miller NR, Flammer J, Meyer P, Weinreb RN, Remonda L, Jaggi GP. Kantonsspital Aarau, CH-5001 Aarau, Switzerland;...
April 30, 2012
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Gonioscopy should be performed using the minimal possible levels of illumination in order to reliably detect appositional angle closure
The Science behind the Tip Anterior chamber angle width varies dramatically with illumination (figure and video in ref. 1) (1,2). Visible...
March 31, 2012
Cataract surgery after trabeculectomy: the effect on trabeculectomy function
Author(s): Husain R, Liang S, Foster PJ, Gazzard G, Bunce C, Chew PT, Oen FT, Khaw PT, Seah SK, Aung T FRCS(Edin), Singapore National Eye Center,...
March 31, 2012
Multipotent Stem Cells from Trabecular Meshwork Become Phagocytic TM cells
Author(s): Du Y, Roh DS, Mann MM, Funderburgh ML, Funderburgh JL, Schuman JS. UPMC Eye Center, Ophthalmology and Visual Science Research Center,...
March 31, 2012
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Laser peripheral iridotomy does not usually result in long-term intraocular pressure control in patients with chronic angle-closure glaucoma
The Science behind the Tip The initial treatment of chronic angle-closure glaucoma is to undertake a laser peripheral iridotomy (PI) to prevent...
February 29, 2012
Outcomes of different management options for malignant glaucoma: a retrospective study
Author(s): Debrouwere V, Stalmans P, Van Calster J, Spileers W, Zeyen T, Stalmans I. Department of Ophthalmology, Kapucijnenvoer 33, 3000, Leuven,...
February 29, 2012
A New Approach to Assess Intracranial White Matter Abnormalities in Glaucoma Patients Changes of Fractional Anisotropy Detected by 3T Diffusion Tensor Imaging
Author(s): Engelhorn T, Michelson G, Waerntges S, Hempel S, El-Rafei A, Struffert T, Doerfler A. Department of Neuroradiology, University of...
February 29, 2012
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Trial lens artifacts can be easily distinguished from glaucomatous field defects
The Science behind the Tip False depressions due to a misaligned trial lens or a lens holder which was placed too far from the patient's eye are...
January 31, 2012
Optic nerve sheath diameter in normal-tension glaucoma patients
Author(s): Jaggi GP, Miller NR, Flammer J, Weinreb RN, Remonda L, Killer HE. Kantonsspital Aarau, Buchserstrasse, CH-5001 Aarau, Switzerland;...
January 31, 2012
Vision deficits precede structural losses in a mouse model of mitochondrial dysfunction and progressive retinal degeneration
Author(s): Laliberté AM, Macpherson TC, Micks T, Yan A, Hill KA Department of Biology, The University of Western Ontario, London, Ontario N6A 5B7,...
January 31, 2012
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In neovascular glaucoma, the immediate injection of intravitreal bevacizumab (Avastin®) usually results in rapid regression of iris new vessels and pain relief
The Science behind the Tip Neovascular glaucoma is a devastating consequence of diseases like proliferative diabetic retinopathy and ischaemic...
December 31, 2011
The Association between Glaucomatous and Other Causes of Optic Neuropathy and Sleep Apnea.
Author(s): Stein JD, Kim DS, Mundy KM, Talwar N, Nan B, Chervin RD, Musch DC. Department of Ophthalmology and Visual Sciences, University of...
December 31, 2011
IOP-Induced Lamina Cribrosa Deformation and Scleral Canal Expansion: Independent or Related?
Author(s): Sigal IA, Yang H, Roberts MD, Grimm JL, Burgoyne CF, Demirel S, Downs JC. Ocular Biomechanics Laboratory. PURPOSE: To study the...
December 31, 2011
Genetic architecture of open angle glaucoma and related determinants
Author(s): Ramdas WD, Amin N, van Koolwijk LM, Janssens AC, Demirkan A, de Jong PT, Aulchenko YS, Wolfs RC, Hofman A, Rivadeneira F, Uitterlinden...
December 31, 2011
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Washout periods vary significantly between glaucoma medications
The Science behind the Tip Knowledge of the washout periods for topical medications is crucial for the evaluation of the effects of their...
November 30, 2011
Shrinkage of the scleral canal during cupping reversal in children.
Author(s): Mochizuki H, Lesley AG, Brandt JD. Department of Ophthalmology and Vision Science, University of California, Davis; Department of...
November 30, 2011
Identification of a Novel Locus for Autosomal Dominant Primary Open Angle Glaucoma on 4q35.1-q35.2.
Author(s): Porter LF, Urquhart JE, O'Donoghue E, Spencer AF, Wade EM, Manson FD, Black GC. School of Biomedicine, The University of Manchester,...
November 30, 2011
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To prevent early hypotony with a non-valved aqeous shunt, always occlude the tube with a suture
The Science behind the Tip The safe use of non-valved aqueous shunt implants, such as the Baerveldt (Advanced Medical Optics, Inc., Irvine,...
October 31, 2011
Intraocular Pressure Control and Long-term Visual Field Loss in the Collaborative Initial Glaucoma Treatment Study
Author(s): Musch DC, Gillespie BW, Niziol LM, Lichter PR, Varma R; CIGTS Study Group. Department of Ophthalmology and Visual Sciences, University...
October 31, 2011
24-Hour IOP Telemetry in the Non-human Primate: Implant System Performance and Initial Characterization of IOP At Multiple Timescales
Author(s): Downs JC, Burgoyne CF, Seigfreid WP, Reynaud JF, Strouthidis NG, Sallee V. Ocular Biomechanics Laboratory, Devers Eye Institute,...
October 31, 2011
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Prostaglandin analogues should be avoided in patients with a history of herpes keratitis
The Science behind the Tip Topical prostaglandins are commonly used as first-line and second-line therapy in patients with ocular hypertension and...
September 30, 2011
Vision loss and recovery after trabeculectomy: risk and associated risk factors
Author(s): Francis BA, Hong B, Winarko J, Kawji S, Dustin L, Chopra V. Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine,...
September 30, 2011
Activated retinal glia mediated axon regeneration in experimental glaucoma
Author(s): Lorber B, Guidi A, Fawcett JW, Martin KR. Centre for Brain Repair, University of Cambridge, Cambridge, UK. Glaucoma, a leading cause of...
September 30, 2011
Trans-lamina cribrosa pressure difference correlated with neuroretinal rim area in glaucoma
Author(s): Ren R, Wang N, Zhang X, Cui T, Jonas JB Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital,...
August 31, 2011
During Glaucoma, {alpha}2-Macroglobulin Accumulates in Aqueous Humor and Binds to Nerve Growth Factor, Neutralizing Neuroprotection
Author(s): Bai Y, Sivori D, Woo SB, Neet KE, Lerner SF, Saragovi HU Lady Davis Institute-Jewish General Hospital PURPOSE: Glaucoma is an optic...
August 31, 2011