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Balancing Glaucoma Care: Tackling Overdiagnosis and Overtreatment to Preserve Patient Quality of Life
The Science behind the Tip In contrast to underdiagnosis, which has been described in...
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Peripapillary Retinoschisis in Glaucoma: A Systematic Review
PURPOSE: The frequent use of optical coherence tomography increased the detection of...
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Evaluating Primary Treatment for People with Advanced Glaucoma: Five-Year Results of the Treatment of Advanced Glaucoma Study
Purpose: To determine whether primary trabeculectomy or medical treatment produces better...
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Activation of the ROCK/MYLK Pathway Affects Complex Molecular and Morphological Changes of the Trabecular Meshwork Associated With Ocular Hypertension
Purpose: The Rho-associated protein kinase and myosin light chain kinase (ROCK/MYLK) pathway...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Facts and myths of cerebrospinal fluid pressure for the physiology of the eye
Author(s): Jonas JB (1), Wang NL (2), Yang D (3), Ritch R (4), Panda-Jonas S (5) 1 Department of Ophthalmology, Medical Faculty Mannheim of the...
March 31, 2015
Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types
Author(s): El-Danaf RN (1), Huberman AD (2) 1 Department of Neurosciences, Neurobiology Section in the Division of Biological Sciences, and...
March 31, 2015
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In patients with narrow filtration angles or primary angle-closure glaucoma who have a patent laser iridotomy, it is safe to prescribe any systemic drugs which have an anti-cholinergic effect on the pupil
The science behind the tip Many commonly used systemic medications have been reported to cause acute congestive angle closure in individuals with...
February 28, 2015
Long-Term Follow-up in Preperimetric Open-Angle Glaucoma: Progression Rates and Associated Factors
Author(s): Kim KE(1), Jeoung JW(2), Kim DM(1), Ahn SJ(3), Park KH(1), Kim SH(4) 1 Department of Ophthalmology, Seoul National University College of...
February 28, 2015
Neuroprotective effects of transcription factor Brn3b in an ocular hypertension rat model of glaucoma
Author(s): Stankowska DL (1), Minton AZ (2), Rutledge MD (3), Mueller BH (4), Phatak NR (5), He S (6), Ma HY (7), Forster MJ (8), Yorio T (9),...
February 28, 2015
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Systemic beta-blocker and nitrates result in a lowering of IOP which has implications for the management of ocular hypertension and glaucoma
The science behind the tip Systemic beta-blockers and nitrates are frequently used in the elderly. It has been known for many years that systemic...
January 31, 2015
The impact of lack of government insured routine eye examinations on the incidence of self-reported glaucoma, cataracts and vision loss
Author(s): Chan CH (1), Trope GE (2), Badley EM (3), Buys Y (4), Jin YP (5) 1 Division of Health Care and Outcomes Research, Toronto Western...
January 31, 2015
Cumulative mtDNA damage and mutations contribute to the progressive loss of RGCs in a rat model of glaucoma
Author(s): Wu J (1), Zhang S (1), Nickerson JM (2), Gao F (3), Sun Z (4), Chen X (3), Zhang S (3), Zhang R (3), Gao F (3), Chen J (3), Luo Y (3),...
January 31, 2015
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Corneal refractive surgery (LASIK) poses a risk to the glaucoma patient
The Science behind the Tip The transient, yet significant, IOP elevation caused by the suction ring may further damage an already compromised optic...
December 31, 2014
Clinical outcomes in cytomegalovirus-positive posner-schlossman syndrome patients treated with topical ganciclovir therapy
Author(s): Su CC(1), Hu FR(2), Wang TH(2), Huang JY(2), Yeh PT(2), Lin CP(2), Wang IJ(3) 1 Department of Ophthalmology, National Taiwan University...
December 31, 2014
Direct optic nerve sheath (DONS) application of Schwann cells prolongs retinal ganglion cell survival in vivo
Author(s): Guo L(1), Davis B(1), Nizari S(1), Normando EM(2), Shi H(3), Galvao J(1), Turner L(1), Shi J(4), Clements M(5), Parrinello S(5),...
December 31, 2014
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If glaucoma progresses despite seemingly controlled IOP, then it may be worthwhile investigating and treating obstructive sleep apnoea syndrome (OSAS)
The Science behind the Tip The exact physiopathology of glaucoma is still poorly understood, but the role of vascular dysregulation has become...
November 30, 2014
Nocturnal systemic hypotension increases the risk of glaucoma progression
Author(s): Charlson ME, de Moraes CG, Link A, Wells MT, Harmon G, Peterson JC, Ritch R, Liebmann JM 1 Center for Integrative Medicine, Weill...
November 30, 2014
Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process
Author(s): Springelkamp H, Höhn R, Mishra A, Hysi PG, Khor CC, Loomis SJ, Bailey JN, Gibson J, Thorleifsson G, Janssen SF, Luo X, Ramdas WD,...
November 30, 2014
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Per-operative use of anti-VEGF agents improves the chance of success of trabeculectomy
The Science behind the Tip Anti-VEGF agents have been widely used in a variety of ocular diseases for their activity in decreasing blood vessel...
October 31, 2014
Optic Nerve Head Deformation in Glaucoma: The Temporal Relationship between Optic Nerve Head Surface Depression and Retinal Nerve Fiber Layer Thinning
Author(s): Xu G(1), Weinreb RN(2), Leung CK(3) 1 Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong,...
October 31, 2014
Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma
Author(s): Hysi PG(1), Cheng CY(2), Springelkamp H(3), Macgregor S(4), Bailey JN(5), Wojciechowski R(6), Vitart V(7), Nag A(8), Hewitt AW(9), Höhn...
October 31, 2014
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After the insertion of a drainage tube, the risk of a delayed supra-choroidal haemorrhage can be reduced by avoiding post-operative hypotony
The Science behind the Tip One of the most serious post-operative complications of tube-shunt surgery is a delayed supra-choroidal haemorrhage,...
September 30, 2014
Rates of retinal nerve fiber layer thinning in glaucoma suspect eyes
Author(s): Miki A(1), Medeiros FA(2), Weinreb RN(2), Jain S(3), He F(3), Sharpsten L(2), Khachatryan N(2), Hammel N(2), Liebmann JM(4), Girkin...
September 30, 2014
Artemin augments survival and axon regeneration in axotomized retinal ganglion cells
Author(s): Omodaka K(1), Kurimoto T, Nakamura O, Sato K, Yasuda M, Tanaka Y, Himori N, Yokoyama Y, Nakazawa T 1 Department of Ophthalmology and...
September 30, 2014
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Temporal placement of a laser peripheral iridotomy is safe and is less likely to result in linear dysphotopsia than if the PI is placed superiorly
The Science behind the Tip To prevent pupil block, a laser peripheral iridotomy (PI) is the initial treatment for patients with primary...
July 31, 2014
The effect of positional changes on intraocular pressure during sleep in patients with and without glaucoma
Author(s): Lazzaro EC(1), Mallick A, Singh M, Reich I, Elmann S, Stefanov DG, Lazzaro DR. 1 Department of Ophthalmology - Scientific Computing...
July 31, 2014
Optic Nerve Head Blood Flow Response to Reduced Ocular Perfusion Pressure by Alteration of Either the Blood Pressure or Intraocular Pressure
Author(s): Wang L(1), Cull GA, Fortune B. 1 Devers Eye Institute, Legacy Research Institute, Portland, OR, USA. ABSTRACT PURPOSE: To test the...
July 31, 2014
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Patients with pseudoexfoliation syndrome often have loss of hearing and should be referred for audiometry
The Science behind the Tip Pseudoexfoliation syndrome is an important cause of glaucoma. It has been known for many years that pseudoexfoliation...
June 30, 2014
Three-year Treatment Outcomes in the Ahmed Baerveldt Comparison Study
Author(s): Barton K(1), Feuer WJ(2), Budenz DL(3), Schiffman J(2), Costa VP(4), Godfrey DG(5), Buys YM(6); Ahmed Baerveldt Comparison Study Group 1...
June 30, 2014