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Gonioscopy is always essential
Angle closure is defined by iridotrabecular contact of ≥180° (1) and the presence or development...
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Association of Blood Pressure and Retinal Nerve Fiber Layer Rates of Thinning in Patients with Moderate to Advanced Glaucoma
Objective: To investigate the influence of baseline blood pressure (BP) on retinal nerve fiber...
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Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use - A Prospective Study
Purpose: To investigate the correlations between aqueous humor total antioxidant capacity (TAC)...
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Care Delivery
SIG Corner Editor: Hana Abouzeid Chair: Anton B. Hommer Co-chair: Gabor Hollo Update on ongoing...
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Comparative Study of Early Safety and Effectiveness Outcomes of the PreserFlo MicroShunt with and without an Intraluminal Suture Stent
Objective: To assess the early safety and effectiveness outcomes of the PreserFlo MicroShunt with...
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Iris Crypts Could Reduce the Chance of Angle Closure: A Computational Biomechanics Study Derived From Clinical and Human Iris Data
Purpose: To investigate the effect of crypts during pupil constriction and dilation on the...
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Glaucoma drainage devices - Is the Paul glaucoma implant suitable for children with glaucoma?
Only a few studies exist on the Paul glaucoma device in children with glaucoma. Compared to Ahmed...
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Comparison of Methods to Deliver Mitomycin C in Trabeculectomy Surgery: a Systematic Review and Meta-analysis
Purpose: Compare different methods to deliver Mitomycin C (MMC) in trabeculectomy surgery....
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Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use - A Prospective Study
Purpose: To investigate the correlations between aqueous humor total antioxidant capacity (TAC)...
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Optic Disc Microvasculature Reduction and Visual Field Progression in Primary Open-Angle Glaucoma
Purpose: To investigate the relationship between optic disc vessel density (ODVD) reduction and...
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Consider cotton wool spots as potential triggers for (non-glaucomatous) nerve fibre bundle defects
It may be tempting to make a glaucoma diagnosis in the presence of a nerve fibre bundle defect...
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Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition
Purpose: We tested the hypothesis that a questionnaire-based risk score predicts the prevalence...
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In clinical practice, anterior segment OCT cannot replace gonioscopy as a method of examining the filtration angle
The science behind the tip The diagnosis and management of all types of glaucoma is dependent on the accurate evaluation of the angle and its...
June 30, 2015
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In every patient with ocular hypertension, search for signs of pseudoexfoliation syndrome as these patients are at significant risk of converting to glaucoma
The science behind the tip Patients with ocular hypertension and pseudoexfoliaton syndrome are twice as likely to convert to glaucoma as those...
June 30, 2015
Structure-Function Relationship Between Bruch's Membrane Opening-Based Optic Nerve Head Parameters and Visual Field Defects in Glaucoma
Author(s): Muth DR, Hirneiß CW PURPOSE: This study was performed to evaluate the structure-function relationship between Bruch's membrane opening...
June 30, 2015
In vivo dynamics of retinal microglial activation during neurodegeneration: confocal ophthalmoscopic imaging and cell morphometry in mouse glaucoma
Author(s): Bosco A (1), Romero CO (2), Ambati BK (3), Vetter ML (2) 1 Department of Neurobiology & Anatomy, University of Utah;...
June 30, 2015
Primary congenital glaucoma outcomes: lessons from 23 years of follow-up
Author(s): Zagora SL(1), Funnell CL(2), Martin FJ(3), Smith JE(3), Hing S(4), Billson FA(3), Veillard AS(5), Jamieson RV(6), Grigg JR(7) 1...
May 31, 2015
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Patients with progressive normal tension glaucoma may benefit from elevation of the head of the bed when they sleep
The science behind the tip Intraocular pressure (IOP) is significantly higher in the supine position than in the sitting position. Progressive...
April 30, 2015
Lamina cribrosa depth in different stages of glaucoma
Author(s): Park SC, Brumm J, Furlanetto RL, Netto C, Liu Y, Tello C, Liebmann JM, Ritch R 1 Department of Ophthalmology, Manhattan Eye, Ear and...
April 30, 2015
A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome
Author(s): Aung T, Ozaki M, Mizoguchi T, Allingham RR, Li Z, Haripriya A, Nakano S, Uebe S, Harder JM, Chan AS, Lee MC, Burdon KP, Astakhov YS,...
April 30, 2015
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RNFL measurement with SD OCT can contribute to glaucoma diagnosis, but only if prior clinical examination has yielded a relevant level of glaucoma suspicion
The science behind the tip It is well known that SD OCT can discriminate with reasonable accuracy between healthy volunteers and glaucoma patients...
March 31, 2015
Facts and myths of cerebrospinal fluid pressure for the physiology of the eye
Author(s): Jonas JB (1), Wang NL (2), Yang D (3), Ritch R (4), Panda-Jonas S (5) 1 Department of Ophthalmology, Medical Faculty Mannheim of the...
March 31, 2015
Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types
Author(s): El-Danaf RN (1), Huberman AD (2) 1 Department of Neurosciences, Neurobiology Section in the Division of Biological Sciences, and...
March 31, 2015
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In patients with narrow filtration angles or primary angle-closure glaucoma who have a patent laser iridotomy, it is safe to prescribe any systemic drugs which have an anti-cholinergic effect on the pupil
The science behind the tip Many commonly used systemic medications have been reported to cause acute congestive angle closure in individuals with...
February 28, 2015
Long-Term Follow-up in Preperimetric Open-Angle Glaucoma: Progression Rates and Associated Factors
Author(s): Kim KE(1), Jeoung JW(2), Kim DM(1), Ahn SJ(3), Park KH(1), Kim SH(4) 1 Department of Ophthalmology, Seoul National University College of...
February 28, 2015
Neuroprotective effects of transcription factor Brn3b in an ocular hypertension rat model of glaucoma
Author(s): Stankowska DL (1), Minton AZ (2), Rutledge MD (3), Mueller BH (4), Phatak NR (5), He S (6), Ma HY (7), Forster MJ (8), Yorio T (9),...
February 28, 2015
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Systemic beta-blocker and nitrates result in a lowering of IOP which has implications for the management of ocular hypertension and glaucoma
The science behind the tip Systemic beta-blockers and nitrates are frequently used in the elderly. It has been known for many years that systemic...
January 31, 2015
The impact of lack of government insured routine eye examinations on the incidence of self-reported glaucoma, cataracts and vision loss
Author(s): Chan CH (1), Trope GE (2), Badley EM (3), Buys Y (4), Jin YP (5) 1 Division of Health Care and Outcomes Research, Toronto Western...
January 31, 2015
Cumulative mtDNA damage and mutations contribute to the progressive loss of RGCs in a rat model of glaucoma
Author(s): Wu J (1), Zhang S (1), Nickerson JM (2), Gao F (3), Sun Z (4), Chen X (3), Zhang S (3), Zhang R (3), Gao F (3), Chen J (3), Luo Y (3),...
January 31, 2015
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Corneal refractive surgery (LASIK) poses a risk to the glaucoma patient
The Science behind the Tip The transient, yet significant, IOP elevation caused by the suction ring may further damage an already compromised optic...
December 31, 2014
Clinical outcomes in cytomegalovirus-positive posner-schlossman syndrome patients treated with topical ganciclovir therapy
Author(s): Su CC(1), Hu FR(2), Wang TH(2), Huang JY(2), Yeh PT(2), Lin CP(2), Wang IJ(3) 1 Department of Ophthalmology, National Taiwan University...
December 31, 2014
Direct optic nerve sheath (DONS) application of Schwann cells prolongs retinal ganglion cell survival in vivo
Author(s): Guo L(1), Davis B(1), Nizari S(1), Normando EM(2), Shi H(3), Galvao J(1), Turner L(1), Shi J(4), Clements M(5), Parrinello S(5),...
December 31, 2014
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If glaucoma progresses despite seemingly controlled IOP, then it may be worthwhile investigating and treating obstructive sleep apnoea syndrome (OSAS)
The Science behind the Tip The exact physiopathology of glaucoma is still poorly understood, but the role of vascular dysregulation has become...
November 30, 2014
Nocturnal systemic hypotension increases the risk of glaucoma progression
Author(s): Charlson ME, de Moraes CG, Link A, Wells MT, Harmon G, Peterson JC, Ritch R, Liebmann JM 1 Center for Integrative Medicine, Weill...
November 30, 2014
Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process
Author(s): Springelkamp H, Höhn R, Mishra A, Hysi PG, Khor CC, Loomis SJ, Bailey JN, Gibson J, Thorleifsson G, Janssen SF, Luo X, Ramdas WD,...
November 30, 2014
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Per-operative use of anti-VEGF agents improves the chance of success of trabeculectomy
The Science behind the Tip Anti-VEGF agents have been widely used in a variety of ocular diseases for their activity in decreasing blood vessel...
October 31, 2014
Optic Nerve Head Deformation in Glaucoma: The Temporal Relationship between Optic Nerve Head Surface Depression and Retinal Nerve Fiber Layer Thinning
Author(s): Xu G(1), Weinreb RN(2), Leung CK(3) 1 Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong,...
October 31, 2014