• Comparative Study of Early Safety and Effectiveness Outcomes of the PreserFlo MicroShunt with and without an Intraluminal Suture Stent

    Objective: To assess the early safety and effectiveness outcomes of the PreserFlo MicroShunt with and without an intraluminal suture stent. Design:...

    Learn more...
    Comparative Study of Early Safety and Effectiveness Outcomes of the PreserFlo MicroShunt with and without an Intraluminal Suture Stent

    Comparative Study of Early Safety and Effectiveness Outcomes of the PreserFlo MicroShunt with and without an Intraluminal Suture Stent

    Objective: To assess the early safety and effectiveness outcomes of the PreserFlo MicroShunt with...

    Learn more...
  • Iris Crypts Could Reduce the Chance of Angle Closure: A Computational Biomechanics Study Derived From Clinical and Human Iris Data

    Purpose: To investigate the effect of crypts during pupil constriction and dilation on the potential for angle closure by performing finite element...

    Learn more...
    Iris Crypts Could Reduce the Chance of Angle Closure: A Computational Biomechanics Study Derived From Clinical and Human Iris Data

    Iris Crypts Could Reduce the Chance of Angle Closure: A Computational Biomechanics Study Derived From Clinical and Human Iris Data

    Purpose: To investigate the effect of crypts during pupil constriction and dilation on the...

    Learn more...
  • Glaucoma drainage devices - Is the Paul glaucoma implant suitable for children with glaucoma?

    Only a few studies exist on the Paul glaucoma device in children with glaucoma. Compared to Ahmed glaucoma Valve or Baerveldt implant, there is...

    Learn more...
    Glaucoma drainage devices - Is the Paul glaucoma implant suitable for children with glaucoma?

    Glaucoma drainage devices - Is the Paul glaucoma implant suitable for children with glaucoma?

    Only a few studies exist on the Paul glaucoma device in children with glaucoma. Compared to Ahmed...

    Learn more...
  • Comparison of Methods to Deliver Mitomycin C in Trabeculectomy Surgery: a Systematic Review and Meta-analysis

    Purpose: Compare different methods to deliver Mitomycin C (MMC) in trabeculectomy surgery. Clinical relevance: Knowing the best way to apply MMC...

    Learn more...
    Comparison of Methods to Deliver Mitomycin C in Trabeculectomy Surgery: a Systematic Review and Meta-analysis

    Comparison of Methods to Deliver Mitomycin C in Trabeculectomy Surgery: a Systematic Review and Meta-analysis

    Purpose: Compare different methods to deliver Mitomycin C (MMC) in trabeculectomy surgery....

    Learn more...
  • Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use - A Prospective Study

    Purpose: To investigate the correlations between aqueous humor total antioxidant capacity (TAC) and glaucoma subtypes, intraocular pressure (IOP),...

    Learn more...
    Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use - A Prospective Study

    Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use - A Prospective Study

    Purpose: To investigate the correlations between aqueous humor total antioxidant capacity (TAC)...

    Learn more...
  • Optic Disc Microvasculature Reduction and Visual Field Progression in Primary Open-Angle Glaucoma

    Purpose: To investigate the relationship between optic disc vessel density (ODVD) reduction and visual field (VF) progression in primary open-angle...

    Learn more...
    Optic Disc Microvasculature Reduction and Visual Field Progression in Primary Open-Angle Glaucoma

    Optic Disc Microvasculature Reduction and Visual Field Progression in Primary Open-Angle Glaucoma

    Purpose: To investigate the relationship between optic disc vessel density (ODVD) reduction and...

    Learn more...
  • Consider cotton wool spots as potential triggers for (non-glaucomatous) nerve fibre bundle defects

    It may be tempting to make a glaucoma diagnosis in the presence of a nerve fibre bundle defect with or without visual field defect when located in...

    Learn more...
    Consider cotton wool spots as potential triggers for (non-glaucomatous) nerve fibre bundle defects

    Consider cotton wool spots as potential triggers for (non-glaucomatous) nerve fibre bundle defects

    It may be tempting to make a glaucoma diagnosis in the presence of a nerve fibre bundle defect...

    Learn more...
  • Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition

    Purpose: We tested the hypothesis that a questionnaire-based risk score predicts the prevalence of patients with primary open-angle glaucoma (POAG)...

    Learn more...
    Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition

    Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition

    Purpose: We tested the hypothesis that a questionnaire-based risk score predicts the prevalence...

    Learn more...
  • Not every ring scotoma is due to glaucoma

    In advanced stages of glaucoma, patients may present with an annular scotoma, also known as ring scotoma, where the retinal sensitivity is...

    Learn more...
    Not every ring scotoma is due to glaucoma

    Not every ring scotoma is due to glaucoma

    In advanced stages of glaucoma, patients may present with an annular scotoma, also known as ring...

    Learn more...
  • Relationship between Blood Pressure and Rates of Glaucomatous Visual Field Progression

    Purpose: To examine the relationship between systemic arterial blood pressure (BP) and the rate of change in standard automated perimetry (SAP) in...

    Learn more...
    Relationship between Blood Pressure and Rates of Glaucomatous Visual Field Progression

    Relationship between Blood Pressure and Rates of Glaucomatous Visual Field Progression

    Purpose: To examine the relationship between systemic arterial blood pressure (BP) and the rate...

    Learn more...
  • Comparison of Outcomes of Deep Sclerectomy, Canaloplasty, and Viscocanaloplasty: A Multi-Centred Study

    Prcis: Deep sclerectomy (DS) and canaloplasty provide better intraocular pressure (IOP) control than viscocanalostomy. DS required less glaucoma...

    Learn more...
    Comparison of Outcomes of Deep Sclerectomy, Canaloplasty, and Viscocanaloplasty: A Multi-Centred Study

    Comparison of Outcomes of Deep Sclerectomy, Canaloplasty, and Viscocanaloplasty: A Multi-Centred Study

    Prcis: Deep sclerectomy (DS) and canaloplasty provide better intraocular pressure (IOP) control...

    Learn more...
  • Macular Oxygen Saturation in Glaucoma Using Retinal Oximetry of Visible Light Optical Coherence Tomography: A Pilot Study

    Purpose: A cross-sectional pilot study to compare macular oxygen saturation (sO2) and associated clinical measurements between normal and glaucoma...

    Learn more...
    Macular Oxygen Saturation in Glaucoma Using Retinal Oximetry of Visible Light Optical Coherence Tomography: A Pilot Study

    Macular Oxygen Saturation in Glaucoma Using Retinal Oximetry of Visible Light Optical Coherence Tomography: A Pilot Study

    Purpose: A cross-sectional pilot study to compare macular oxygen saturation (sO2) and associated...

    Learn more...
Cataract surgery after trabeculectomy increases the risk of bleb failure and this risk is increased if the time between trabeculectomy and cataract surgery is short

Tip of the month

Cataract surgery after trabeculectomy increases the risk of bleb failure and this risk is increased if the time between trabeculectomy and cataract surgery is short

The Science behind the Tip Trabeculectomy surgery is a recognised risk factor for the subsequent development of cataract. Phacoemulsification with...

November 30, 2013

Pathogenesis and clinical implications of optic disk hemorrhage in glaucoma

Clinical paper of the month

Pathogenesis and clinical implications of optic disk hemorrhage in glaucoma

Author(s): Suh MH, Park KH. Department of Ophthalmology, Haeundae Paik Hospital, Busan, Korea; Department of Ophthalmology, Inje University College...

November 30, 2013

Identification of retinal ganglion cell neuroprotection conferred by platelet-derived growth factor through analysis of the mesenchymal stem cell secretome

Experimental Paper of the Month

Identification of retinal ganglion cell neuroprotection conferred by platelet-derived growth factor through analysis of the mesenchymal stem cell secretome

Author(s): Johnson TV, Dekorver NW, Levasseur VA, Osborne A, Tassoni A, Lorber B, Heller JP, Villasmil R, Bull ND, Martin KR, Tomarev SI 1 Section...

November 30, 2013

Generic drops can differ from brand drops and it may be necessary to monitor patients more closely after switching

Tip of the month

Generic drops can differ from brand drops and it may be necessary to monitor patients more closely after switching

The Science behind the Tip In order to be approved for general use, a generic drug has to show the criterion of essential similarity when compared...

October 31, 2013

Lifetime Risk of Blindness in Open-Angle Glaucoma

Clinical paper of the month

Lifetime Risk of Blindness in Open-Angle Glaucoma

Author(s): Peters D, Bengtsson B, Heijl A Department of Ophthalmology, Lund University, Skåne University Hospital, Malmö, Sweden. Electronic...

October 31, 2013

Immune response against ocular tissues after immunization with optic nerve antigens in a model of autoimmuneglaucoma

Experimental Paper of the Month

Immune response against ocular tissues after immunization with optic nerve antigens in a model of autoimmuneglaucoma

Author(s): Joachim SC, Reinehr S, Kuehn S, Laspas P, Gramlich OW, Kuehn M, Tischoff I, von Pein HD, Dick HB, Grus FH Experimental Eye Research...

October 31, 2013

The measurement of retinal nerve fibre thickness is helpful in determining which patients with ocular hypertension will develop glaucoma

Tip of the month

The measurement of retinal nerve fibre thickness is helpful in determining which patients with ocular hypertension will develop glaucoma

The Science behind the Tip In patients with ocular hypertension, moderate to severe retinal nerve fibre layer (RNFL) atrophy at baseline has been...

September 30, 2013

The Ahmed Versus Baerveldt Study: Three-Year Treatment Outcomes

Clinical paper of the month

The Ahmed Versus Baerveldt Study: Three-Year Treatment Outcomes

Author(s): Christakis PG, Tsai JC, Kalenak JW, Zurakowski D, Cantor LB, Kammer JA, Ahmed II. Department of Ophthalmology and Vision Sciences,...

September 30, 2013

Onset and Progression of Peripapillary Retinal Nerve Fiber Layer (RNFL) Retardance Changes Occur Earlier than RNFL Thickness Changes in Experimental Glaucoma

Experimental Paper of the Month

Onset and Progression of Peripapillary Retinal Nerve Fiber Layer (RNFL) Retardance Changes Occur Earlier than RNFL Thickness Changes in Experimental Glaucoma

Author(s): Fortune B, Burgoyne CF, Cull G, Reynaud J, Wang L. Devers Eye Institute, Legacy Research Institute, 1225 NE 2nd Avenue, 3rd Floor,...

September 30, 2013

Rho-associated kinase inhibitors: A novel glaucoma therapy

Clinical paper of the month

Rho-associated kinase inhibitors: A novel glaucoma therapy

Author(s): Inoue T, Tanihara H. Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto, Japan....

July 31, 2013

Ocular Rigidity, Outflow facility, Ocular Pulse Amplitude and Pulsatile Ocular Blood Flow in Open AngleGlaucoma; a manometric study

Experimental Paper of the Month

Ocular Rigidity, Outflow facility, Ocular Pulse Amplitude and Pulsatile Ocular Blood Flow in Open AngleGlaucoma; a manometric study

Author(s): Dastiridou AI, Tsironi EE, Tsilimbaris M, Ginis H, Karyotakis N, Cholevas P, Androudi S, Pallikaris IG. Ophthalmology Department,...

July 31, 2013

Post-traumatic angle-recession glaucoma is difficult to manage and surgical intervention is often required

Tip of the month

Post-traumatic angle-recession glaucoma is difficult to manage and surgical intervention is often required

The Science behind the Tip Anterior chamber angle recession is the commonest physical sign of previous blunt trauma to the eye. Raised intraocular...

June 30, 2013

Prevalence and Severity of Undetected Manifest Glaucoma: Results from the Early Manifest Glaucoma Trial Screening

Clinical paper of the month

Prevalence and Severity of Undetected Manifest Glaucoma: Results from the Early Manifest Glaucoma Trial Screening

Author(s): Heijl A, Bengtsson B, Oskarsdottir SE. Lund University, Department of Clinical Sciences Malmö, Ophthalmology, Skåne University Hospital,...

June 30, 2013

Acetylcholinesterase inhibition promotes retinal vasoprotection and increases ocular blood flow in experimental glaucoma

Experimental Paper of the Month

Acetylcholinesterase inhibition promotes retinal vasoprotection and increases ocular blood flow in experimental glaucoma

Author(s): Almasieh M, Macintyre JN, Pouliot M, Casanova C, Vaucher E, Kelly ME, Di Polo A. Department of Pathology and Cell Biology and Groupe de...

June 30, 2013

The use of Ginkgo biloba may increase the risk of bleeding

Tip of the month

The use of Ginkgo biloba may increase the risk of bleeding

The Science behind the Tip Extracts of the leaves of the Asiatic tree Ginkgo biloba (GBE) provide protection against mitochondrial oxidative damage...

May 31, 2013

The eye and the heart

Clinical paper of the month

The eye and the heart

Author(s): Flammer J, Konieczka K, Bruno R M, Virdis A, Flammer A J, Taddei S The vasculature of the eye and the heart share several common...

May 31, 2013

Reduction in Blood Glutathione Levels Occurs Similarly in Patients with Primary-Open Angle or Normal Tension Glaucoma

Experimental Paper of the Month

Reduction in Blood Glutathione Levels Occurs Similarly in Patients with Primary-Open Angle or Normal Tension Glaucoma

Author(s): Gherghel D, Mroczkowska S, Qin L Vascular Research Laboratory, Ophthalmic Research Group, Aston University, School of Life and Health...

May 31, 2013

If surgery is required to control IOP in a patient with nanophthalmos, phacoemulsification with IOL implantation is a good option, but the complication rate is high

Tip of the month

If surgery is required to control IOP in a patient with nanophthalmos, phacoemulsification with IOL implantation is a good option, but the complication rate is high

The Science behind the Tip Nanophthalmos, small eye-big trouble, is a form of microophthalmos which is not accompanied by other congenital...

April 30, 2013

How Does Glaucoma Look?: Patient Perception of Visual Field Loss

Clinical paper of the month

How Does Glaucoma Look?: Patient Perception of Visual Field Loss

Author(s): Crabb DP, Smith ND, Glen FC, Burton R, Garway-Heath DF Department of Optometry and Visual Science, City University London, London,...

April 30, 2013

Tissue engineering the retinal ganglion cell nerve fiber layer

Experimental Paper of the Month

Tissue engineering the retinal ganglion cell nerve fiber layer

Author(s): Kador KE, Montero RB, Venugopalan P, Hertz J, Zindell AN, Valenzuela DA, Uddin MS, Lavik EB, Muller KJ, Andreopoulos FM, Goldberg JL...

April 30, 2013

Indefinite use of cycloplegics can be the last resort when surgery for malignant glaucoma has failed

Tip of the month

Indefinite use of cycloplegics can be the last resort when surgery for malignant glaucoma has failed

The Science behind the Tip Malignant glaucoma or aqueous misdirection is a rare but feared complication of anterior segment surgery. It occurs in...

March 31, 2013

Treatment Outcomes in Malignant Glaucoma

Clinical paper of the month

Treatment Outcomes in Malignant Glaucoma

Author(s): Dave P, Senthil S, Rao HL, Garudadri CS. L. V. Prasad Eye Institute, Hyderabad, India. PURPOSE: To report treatment outcomes in...

March 31, 2013

Discovery of novel human aquaporin-1 blockers

Experimental Paper of the Month

Discovery of novel human aquaporin-1 blockers

Author(s): Seeliger D, Zapater C, Krenc D, Haddoub R, Flitsch S, Beitz E, Cerdà J, de Groot BL. Human aquaporin-1 (hAQP1) is a water channel found...

March 31, 2013

Young men of European ancestry with angle-closure require thorough investigation

Tip of the month

Young men of European ancestry with angle-closure require thorough investigation

The Science behind the Tip Primary angle closure glaucoma is rare in younger white adults, with an estimated age specific prevalence of 0.02% for...

February 28, 2013

Protective effect of lipoic acid against oxidative stress is mediated by Keap1/Nrf2-dependent heme oxygenase-1 induction in the RGC-5 cell line

Experimental Paper of the Month

Protective effect of lipoic acid against oxidative stress is mediated by Keap1/Nrf2-dependent heme oxygenase-1 induction in the RGC-5 cell line

Author(s): Koriyama Y, Nakayama Y, Matsugo S, Kato S. Department of Molecular Neurobiology, Graduate School of Medicine. Electronic address:...

February 28, 2013