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  • Exfoliation SIG Corner

    SIG Corner Editor: Hana Abouzeid Chair: Gabor Hollo Co-chair: Anastasios G. Konstas The goal of this SIG is to increase ophthalmologists’ knowledge...

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    Exfoliation SIG Corner

    Exfoliation SIG Corner

    SIG Corner Editor: Hana Abouzeid Chair: Gabor Hollo Co-chair: Anastasios G. Konstas The goal of...

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  • IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

    Purpose: Expansion of the suprachoroidal space (SCS) by a hydrogel injection has been shown to reduce intraocular pressure (IOP) in rabbits as a...

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    IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

    IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

    Purpose: Expansion of the suprachoroidal space (SCS) by a hydrogel injection has been shown to...

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  • Relationship between Intraocular Pressure Fluctuation and Visual Field Progression Rates in the United Kingdom Glaucoma Treatment Study

    Purpose: To investigate whether intraocular pressure (IOP) fluctuation is associated independently with the rate of visual field (VF) progression...

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    Relationship between Intraocular Pressure Fluctuation and Visual Field Progression Rates in the United Kingdom Glaucoma Treatment Study

    Relationship between Intraocular Pressure Fluctuation and Visual Field Progression Rates in the United Kingdom Glaucoma Treatment Study

    Purpose: To investigate whether intraocular pressure (IOP) fluctuation is associated...

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  • Using anterior segment OCT to risk-stratify primary angle closure suspects

    Gonioscopy is the clinical standard for detecting patients at risk for primary angle closure glaucoma (PACG). However, anterior chamber angle...

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    Using anterior segment OCT to risk-stratify primary angle closure suspects

    Using anterior segment OCT to risk-stratify primary angle closure suspects

    Gonioscopy is the clinical standard for detecting patients at risk for primary angle closure...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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Rate and Pattern of Rim Area Loss in Healthy and Progressing Glaucoma Eyes

Clinical paper of the month

Rate and Pattern of Rim Area Loss in Healthy and Progressing Glaucoma Eyes

Author(s): Hammel N (1), Belghith A (1), Bowd C (1), Medeiros FA (1), Sharpsten L (1), Mendoza N (1), Tatham AJ (1), Khachatryan N (1), Liebmann JM...

March 31, 2016

Retinal and Optic Nerve Damage is Associated with Early Glial Responses in an Experimental Autoimmune Glaucoma Model

Experimental Paper of the Month

Retinal and Optic Nerve Damage is Associated with Early Glial Responses in an Experimental Autoimmune Glaucoma Model

Author(s): Noristani R (1), Kuehn S (1), Stute G (1), Reinehr S (1), Stellbogen M (1), Dick HB (1), Joachim SC (2) 1 Experimental Eye Research...

March 31, 2016

If a choroidal effusion develops after surgery in a patient with nanophthalmos then a partial thickness lamellar sclerectomy is an effective therapeutic option

Tip of the month

If a choroidal effusion develops after surgery in a patient with nanophthalmos then a partial thickness lamellar sclerectomy is an effective therapeutic option

The science behind the tip Raised IOP and secondary glaucoma are common late consequences of nanophthalmos (axial length less than 20mm)....

January 31, 2016

Microstructure of Peripapillary Atrophy and Subsequent Visual Field Progression in Treated Primary Open-Angle Glaucoma

Clinical paper of the month

Microstructure of Peripapillary Atrophy and Subsequent Visual Field Progression in Treated Primary Open-Angle Glaucoma

Author(s): Yamada H (1), Akagi T (2), Nakanishi H (1), Ikeda HO (1), Kimura Y (1), Suda K (1), Hasegawa T (1), Yoshikawa M (1), Iida Y (1),...

January 31, 2016

Decreased Energy Capacity and Increased Autophagic Activity in Optic Nerve Axons With Defective Anterograde Transport

Experimental Paper of the Month

Decreased Energy Capacity and Increased Autophagic Activity in Optic Nerve Axons With Defective Anterograde Transport

Author(s): Kleesattel D, Crish SD, Inman DM PURPOSE: Autophagy is a critical process, compromised in neurodegenerative disease, by which terminally...

January 31, 2016

Patients with neovascular glaucoma secondary to ocular ischaemia syndrome need pan-retinal photocoagulation and urgent referral to a physician

Tip of the month

Patients with neovascular glaucoma secondary to ocular ischaemia syndrome need pan-retinal photocoagulation and urgent referral to a physician

The science behind the tip The cause of neovascular glaucoma in two thirds of patients is either proliferative diabetic retinopathy or an ischaemic...

December 31, 2015

Trabeculectomy Can Improve Long-Term Visual Function in Glaucoma

Clinical paper of the month

Trabeculectomy Can Improve Long-Term Visual Function in Glaucoma

Author(s): Caprioli J (1), de Leon JM (2), Azarbod P (2), Chen A (2), Morales E (2), Nouri-Mahdavi K (2), Coleman A (2), Yu F (3), Afifi A (4) 1...

December 31, 2015

Measurement of Systemic Mitochondrial Function in Advanced Primary Open-Angle Glaucoma and Leber Hereditary Optic Neuropathy

Experimental Paper of the Month

Measurement of Systemic Mitochondrial Function in Advanced Primary Open-Angle Glaucoma and Leber Hereditary Optic Neuropathy

Author(s): Van Bergen NJ (1), Crowston JG (1), Craig JE (2), Burdon KP (2), Kearns LS (1), Sharma S (2), Hewitt AW (1), Mackey DA (3), Trounce IA...

December 31, 2015

Avoid the upper nasal quadrant when inserting an aqueous drainage implant, as it can result in acquired Brown syndrome

Tip of the month

Avoid the upper nasal quadrant when inserting an aqueous drainage implant, as it can result in acquired Brown syndrome

The science behind the tip Aqueous drainage tubes are commonly used in the surgical treatment of refractory glaucoma. New onset persistent diplopia...

November 30, 2015

Visual impairment and vision-related quality of life in the Early Manifest Glaucoma Trial after 20 years of follow-up

Clinical paper of the month

Visual impairment and vision-related quality of life in the Early Manifest Glaucoma Trial after 20 years of follow-up

Author(s): Peters D (1), Heijl A (1), Brenner L (2), Bengtsson B (1) 1 Department of Ophthalmology, Skåne University Hospital, Lund University,...

November 30, 2015

Intraocular pressure reduction and neuroprotection conferred by bone marrow-derived mesenchymal stem cells in an animal model of glaucoma

Experimental Paper of the Month

Intraocular pressure reduction and neuroprotection conferred by bone marrow-derived mesenchymal stem cells in an animal model of glaucoma

Author(s): Roubeix C (1,2,3), Godefroy D (4,5,6), Mias C (7), Sapienza A (8,9,10), Riancho L (11,12,13), Degardin J (14,15,16), Fradot V...

November 30, 2015

Artifacts in the SD-OCT images in a patient with glaucoma or suspected glaucoma may lead to an erroneous conclusion

Tip of the month

Artifacts in the SD-OCT images in a patient with glaucoma or suspected glaucoma may lead to an erroneous conclusion

The science behind the tip Structural measurements of the optic disc and retinal nerve fibre layer (RNFL) have become an indispensable tool in the...

October 31, 2015

Association between Platelet Function and Disc Hemorrhage in Patients with Normal Tension Glaucoma: A prospective cross-sectional study

Clinical paper of the month

Association between Platelet Function and Disc Hemorrhage in Patients with Normal Tension Glaucoma: A prospective cross-sectional study

Author(s): Shim SH (1), Kim JM (2), Woo HY (3), Shin KU (1), Koh JW (4), Park KH (5) 1 Department of Ophthalmology, Kangbuk Samsung Hospital,...

October 31, 2015

Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation

Experimental Paper of the Month

Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation

Author(s): Cueva Vargas JL (1), Osswald IK (2), Unsain N (3), Aurousseau MR (2), Barker PA (3), Bowie D (2), Di Polo A (4) 1 Department of...

October 31, 2015

The ISNT rule is of limited benefit in differentiating early glaucoma from normal

Tip of the month

The ISNT rule is of limited benefit in differentiating early glaucoma from normal

The science behind the tip The ISNT rule states that a healthy optic disc has a characteristic configuration of the neuro-retinal rim; which is...

September 30, 2015

Patterns of Glaucoma Medication Adherence over Four Years of Follow-Up

Clinical paper of the month

Patterns of Glaucoma Medication Adherence over Four Years of Follow-Up

Author(s): Newman-Casey PA (1), Blachley T (2), Lee PP (3), Heisler M (4), Farris KB (5), Stein JD (3) 1 Department of Ophthalmology and Visual...

September 30, 2015

In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS

Experimental Paper of the Month

In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS

Author(s): Takihara Y (1), Inatani M (2), Eto K (3), Inoue T (4), Kreymerman A (5), Miyake S (6), Ueno S (7), Nagaya M (7), Nakanishi A (7), Iwao K...

September 30, 2015

Patients with advanced glaucoma who are to undergo trabeculectomy should be warned that there is a small risk of permanent visual loss as a consequence of the surgery

Tip of the month

Patients with advanced glaucoma who are to undergo trabeculectomy should be warned that there is a small risk of permanent visual loss as a consequence of the surgery

The science behind the tip Transient visual disturbance after trabeculectomy is common and it can take several months for the vision to recover....

July 31, 2015

Relationship Between Daytime Variability of Blood Pressure or Ocular Perfusion Pressure and Glaucomatous Visual Field Progression

Clinical paper of the month

Relationship Between Daytime Variability of Blood Pressure or Ocular Perfusion Pressure and Glaucomatous Visual Field Progression

Author(s): Lee J (1), Choi J (2), Jeong D (1), Kim S (1), Kook MS (3) 1 Department of Ophthalmology, College of Medicine, University of Ulsan, Asan...

July 31, 2015

Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and Rat

Experimental Paper of the Month

Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and Rat

Author(s): Bogner B (1), Boye SL (2), Min SH (2), Peterson JJ (2), Ruan Q (2), Zhang Z (1), Reitsamer HA (1), Hauswirth WW (2), Boye SE (2) 1...

July 31, 2015

In clinical practice, anterior segment OCT cannot replace gonioscopy as a method of examining the filtration angle

Tip of the month

In clinical practice, anterior segment OCT cannot replace gonioscopy as a method of examining the filtration angle

The science behind the tip The diagnosis and management of all types of glaucoma is dependent on the accurate evaluation of the angle and its...

June 30, 2015

In every patient with ocular hypertension, search for signs of pseudoexfoliation syndrome as these patients are at significant risk of converting to glaucoma

Tip of the month

In every patient with ocular hypertension, search for signs of pseudoexfoliation syndrome as these patients are at significant risk of converting to glaucoma

The science behind the tip Patients with ocular hypertension and pseudoexfoliaton syndrome are twice as likely to convert to glaucoma as those...

June 30, 2015

Structure-Function Relationship Between Bruch's Membrane Opening-Based Optic Nerve Head Parameters and Visual Field Defects in Glaucoma

Clinical paper of the month

Structure-Function Relationship Between Bruch's Membrane Opening-Based Optic Nerve Head Parameters and Visual Field Defects in Glaucoma

Author(s): Muth DR, Hirneiß CW PURPOSE: This study was performed to evaluate the structure-function relationship between Bruch's membrane opening...

June 30, 2015

In vivo dynamics of retinal microglial activation during neurodegeneration: confocal ophthalmoscopic imaging and cell morphometry in mouse glaucoma

Experimental Paper of the Month

In vivo dynamics of retinal microglial activation during neurodegeneration: confocal ophthalmoscopic imaging and cell morphometry in mouse glaucoma

Author(s): Bosco A (1), Romero CO (2), Ambati BK (3), Vetter ML (2) 1 Department of Neurobiology & Anatomy, University of Utah;...

June 30, 2015

Primary congenital glaucoma outcomes: lessons from 23 years of follow-up

Clinical paper of the month

Primary congenital glaucoma outcomes: lessons from 23 years of follow-up

Author(s): Zagora SL(1), Funnell CL(2), Martin FJ(3), Smith JE(3), Hing S(4), Billson FA(3), Veillard AS(5), Jamieson RV(6), Grigg JR(7) 1...

May 31, 2015