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Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization
Purpose: Glaucoma is the primary cause of permanent vision loss worldwide. However, the...
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Quality of Life and Primary Open-Angle Glaucoma in the Ocular Hypertension Treatment Study
Importance: If preperimetric glaucoma reduces patient-reported vision-related quality of life...
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Fatal beauty: which cosmetics are your glaucoma patients using?
Colorism refers to the difference in social treatment between light-skinned and dark-skinned...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Indefinite use of cycloplegics can be the last resort when surgery for malignant glaucoma has failed
The Science behind the Tip Malignant glaucoma or aqueous misdirection is a rare but feared complication of anterior segment surgery. It occurs in...
March 31, 2013
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Young men of European ancestry with angle-closure require thorough investigation
The Science behind the Tip Primary angle closure glaucoma is rare in younger white adults, with an estimated age specific prevalence of 0.02% for...
February 28, 2013
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Intravitreal steroids should be used with caution in patients with glaucoma
The Science behind the Tip In recent years it has become common practice to inject steroids into the vitreous to reduce macular oedema or ocular...
December 31, 2012
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Long-term application of benzalkonium chloride increases the risk of filtration surgery failure
The Science behind the Tip Glaucoma medication solutions usually contain the preservative benzalkonium chloride (BAK) in concentrations varying...
November 30, 2012
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In patients with pseudoexfoliation glaucoma, phacoemulsification with IOL implantation can result in a late, sustained reduction in intraocular pressure
The Science behind the Tip Raised intraocular pressure (IOP) in an eye with pseudoexfoliation syndrome results from pigment and exfoliation...
October 31, 2012
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Topical carbonic anhydrase inhibitors can cause damage in corneas with severe endothelial dysfunction
The Science behind the Tip The enzyme carbonic anhydrase is present in the corneal endothelium where it is involved in fluid transport (1). It thus...
September 30, 2012
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In patients with progressive normal tension glaucoma, the use of topical brimonidine may help to preserve visual function
The Science behind the Tip A recent study has shown that visual function is more likely to be preserved with brimonidine 2% than with timolol 0.5%...
June 30, 2012
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A dry eye can hamper visual field test interpretation
The Science behind the Tip During visual field (VF) testing the cornea of patients with severe dry eye condition can get dry to such an extent as...
May 31, 2012
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Laser peripheral iridotomy can reduce the intraocular pressure in pigment dispersion syndrome, but may not prevent glaucoma
The Science behind the Tip Nd-YAG laser peripheral iridotomy (PI) eliminates the reverse pressure gradient and intermittent posterior bowing of the...
April 30, 2012
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Gonioscopy should be performed using the minimal possible levels of illumination in order to reliably detect appositional angle closure
The Science behind the Tip Anterior chamber angle width varies dramatically with illumination (figure and video in ref. 1) (1,2). Visible...
March 31, 2012
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Laser peripheral iridotomy does not usually result in long-term intraocular pressure control in patients with chronic angle-closure glaucoma
The Science behind the Tip The initial treatment of chronic angle-closure glaucoma is to undertake a laser peripheral iridotomy (PI) to prevent...
February 29, 2012
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Trial lens artifacts can be easily distinguished from glaucomatous field defects
The Science behind the Tip False depressions due to a misaligned trial lens or a lens holder which was placed too far from the patient's eye are...
January 31, 2012
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In neovascular glaucoma, the immediate injection of intravitreal bevacizumab (Avastin®) usually results in rapid regression of iris new vessels and pain relief
The Science behind the Tip Neovascular glaucoma is a devastating consequence of diseases like proliferative diabetic retinopathy and ischaemic...
December 31, 2011
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Washout periods vary significantly between glaucoma medications
The Science behind the Tip Knowledge of the washout periods for topical medications is crucial for the evaluation of the effects of their...
November 30, 2011
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To prevent early hypotony with a non-valved aqeous shunt, always occlude the tube with a suture
The Science behind the Tip The safe use of non-valved aqueous shunt implants, such as the Baerveldt (Advanced Medical Optics, Inc., Irvine,...
October 31, 2011
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Prostaglandin analogues should be avoided in patients with a history of herpes keratitis
The Science behind the Tip Topical prostaglandins are commonly used as first-line and second-line therapy in patients with ocular hypertension and...
September 30, 2011
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Rim/disc ratio is a more sensitive parameter than cup/disc ratio
The Science behind the Tip Routine fundus observation of the optic disc is helpful in the diagnosis of early glaucoma and it is often key in the...
June 30, 2011
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In patients with juvenile-onset chronic open-angle glaucoma, trabeculectomy with mitomycin C is usually required to prevent progressive visual loss
The Science behind the Tip Juvenile-onset chronic open-angle glaucoma is inherited in an autosomal dominant fashion with high penetrance....
May 31, 2011
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The advantage of adding a 3rd or 4th drug may be negligible
The Science behind the Tip With the arrival of combination products, our threshold for prescribing multiple glaucoma medications has significantly...
April 30, 2011
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The most effective treatment of glaucoma associated with epithelial downgrowth is to insert a drainage implant
The Science behind the Tip Epithelial downgrowth into the anterior chamber is an extremely rare cause of glaucoma after anterior segment incisional...
March 31, 2011
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Chronic miotics can be helpful in case of plateau iris configuration
The Science behind the Tip Long term miotics are seldom prescribed nowadays. Still the drugs remain useful in case of plateau iris configuration, a...
February 28, 2011
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To reduce the risk of late bleb-related infection, avoid multiple-dose eye drops in patients who have previously undergone trabeculectomy with mitomycin C
The Science behind the Tip Bleb-related infection is a devastating and potentially blinding late consequence of trabeculectomy, particularly if...
January 31, 2011
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Small field depressions can be more worrying than large ones
The Science behind the Tip Much of the decision making in modern glaucoma practice is based on automated visual field test results. Careful...
December 31, 2010
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The cataract surgeon should be informed that the patient has pseudo-exfoliation syndrome
The Science behind the Tip Although the diagnosis of pseudo-exfoliation syndrome (PEX) with a fully dilated pupil in an elderly patient should pose...
October 31, 2010
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If conservative measures are unsuccessful in the management of malignant glaucoma, phaco with IOL combined with posterior capsulotomy and anterior vitrectomy usually is
The Science behind the Tip Malignant glaucoma in a phakic eye typically follows incisional surgery for primary angle-closure glaucoma. Shallowing...
September 30, 2010