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Optic Disc Microvasculature Reduction and Visual Field Progression in Primary Open-Angle Glaucoma
Purpose: To investigate the relationship between optic disc vessel density (ODVD) reduction and...
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Consider cotton wool spots as potential triggers for (non-glaucomatous) nerve fibre bundle defects
It may be tempting to make a glaucoma diagnosis in the presence of a nerve fibre bundle defect...
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Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition
Purpose: We tested the hypothesis that a questionnaire-based risk score predicts the prevalence...
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Not every ring scotoma is due to glaucoma
In advanced stages of glaucoma, patients may present with an annular scotoma, also known as ring...
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Relationship between Blood Pressure and Rates of Glaucomatous Visual Field Progression
Purpose: To examine the relationship between systemic arterial blood pressure (BP) and the rate...
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Comparison of Outcomes of Deep Sclerectomy, Canaloplasty, and Viscocanaloplasty: A Multi-Centred Study
Prcis: Deep sclerectomy (DS) and canaloplasty provide better intraocular pressure (IOP) control...
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Macular Oxygen Saturation in Glaucoma Using Retinal Oximetry of Visible Light Optical Coherence Tomography: A Pilot Study
Purpose: A cross-sectional pilot study to compare macular oxygen saturation (sO2) and associated...
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Childhood Glaucoma
SIG Corner Editor: Hana Abouzeid Chair: Esther Hoffmann Co-chair: Zeynep Aktas Childhood glaucoma...
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Avoid premature removal of the intraluminal suture in glaucoma drainage devices to minimize the risk of hypotony
While prolene suture removal is an effective method for reducing IOP at the slit-lamp, removing...
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Biomechanics-Function in Glaucoma: Improved Visual Field Predictions from IOP-Induced Neural Strains
Purpose: (1) To assess whether neural tissue structure and biomechanics could predict functional...
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Validation of a Visual Field Prediction Tool for Glaucoma: A Multicenter Study Involving Patients With Glaucoma in the United Kingdom
Purpose: A previously developed machine-learning approach with Kalman filtering technology...
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Fatal beauty: which cosmetics are your glaucoma patients using?
Colorism refers to the difference in social treatment between light-skinned and dark-skinned...
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Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine
Author(s): Fini ME (1), Schwartz SG (2), Gao X (3), Jeong S (4), Patel N (5), Itakura T (6), Price MO (7), Price FW Jr (8), Varma R (9), Stamer WD...
November 30, 2016
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Despite the increased central corneal thickness (CCT) that may follow lamellar corneal surgery, reliable IOP measurements can be obtained with Goldmann applanation tonometry or Pascal dynamic tomography
The Science behind the Tip Lamellar corneal surgery (DSAEK, DMEK) is replacing penetrating keratoplasty, because visual recovery is better and...
October 31, 2016
Monitoring ocular hypertension, how much and how often? A cost-effectiveness perspective
Author(s): Hernández R(1), Burr JM(2), Vale L(3), Azuara-Blanco A(4), Cook JA(5), Banister K(6), Tuulonen A(7), Ryan M(1); Surveillance of Ocular...
October 31, 2016
Assessing the Association of Mitochondrial Genetic Variation With Primary Open-Angle Glaucoma Using Gene-Set Analyses
Author(s): Khawaja AP(1), Cooke Bailey JN(2), Kang JH(3), Allingham RR(4), Hauser MA(5), Brilliant M(6), Budenz DL(7), Christen WG(8), Fingert...
October 31, 2016
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In patients with pigment dispersion syndrome, YAG laser peripheral iridotomy can reduce the risk of raised intraocular pressure (IOP) in some patients, but does not prevent glaucoma
The Science behind the Tip Pigment dispersion syndrome arises from posterior bowing of the iris secondary to reverse pupil block. This causes...
September 30, 2016
The Relative Odds of Progressing by Structural and Functional Tests in Glaucoma
Author(s): Abe RY, Diniz-Filho A, Zangwill LM, Gracitelli CP, Marvasti AH, Weinreb RN, Baig S, Medeiros FA PURPOSE: The purpose of this study was...
September 30, 2016
Glaucoma related Proteomic Alterations in Human Retina Samples
Author(s): Funke S (1), Perumal N (1), Beck S (1), Gabel-Scheurich S (1), Schmelter C (1), Teister J (1), Gerbig C (1), Gramlich OW (1,2), Pfeiffer...
September 30, 2016
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An optic disc haemorrhage indicates ongoing structural change and is an important sign of progressive glaucoma
The Science behind the Tip Prospective studies have shown that splinter-shaped haemorrhages at the optic disc margin are an important risk factor...
July 31, 2016
Importance of Normal Aging in Estimating the Rate of Glaucomatous Neuroretinal Rim and Retinal Nerve Fiber Layer Loss
Author(s): Vianna JR (1), Danthurebandara VM (1), Sharpe GP (1), Hutchison DM (1), Belliveau AC (1), Shuba LM (1), Nicolela MT (1), Chauhan BC (2)...
July 31, 2016
Predegenerated Schwann cells-a novel prospect for cell therapy for glaucoma: neuroprotection, neuroregeneration and neuroplasticity
Author(s): Smedowski A (1,2,3), Liu X (4), Pietrucha-Dutczak M (1), Matuszek I (1), Varjosalo M (4), Lewin-Kowalik J (1) 1 Chair and Department of...
July 31, 2016
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Gradual intraocular pressure (IOP) elevation with a need for additional treatment is common in pseudophakic glaucoma patients following Nd; YAG laser posterior capsulotomy
The Science behind the Tip Nd: YAG laser capsulotomy is known to increase the IOP in some normal patients in the short term, with the maximum IOP...
June 30, 2016
Visual impairment and vision-related quality of life in the Early Manifest Glaucoma Trial after 20 years of follow-up
Author(s): Peters D (1), Heijl A (1), Brenner L (2), Bengtsson B (1) 1 Department of Ophthalmology, Skåne University Hospital, Lund University,...
June 30, 2016
Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma
Author(s): Vithana EN (1), Khor CC, Qiao C, Nongpiur ME, George R, Chen LJ, Do T, Abu-Amero K, Huang CK, Low S, Tajudin LS, Perera SA, Cheng CY, Xu...
June 30, 2016
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Early detection of hypotony maculopathy is essential, as permanent chorioretinal changes and poor visual outcomes will occur without rapid surgical intervention
The science behind the tip Hypotony maculopathy is an uncommon but serious late complication of glaucoma filtration surgery, particularly when an...
May 31, 2016
Diabetes, Triglyceride Levels, and Other Risk Factors for Glaucoma in the National Health and Nutrition Examination Survey 2005-2008
Author(s): Ko F (1), Boland MV (2), Gupta P (3), Gadkaree SK (4), Vitale S (5), Guallar E (6), Zhao D (6), Friedman DS (7) 1 Glaucoma, Moorfields...
May 31, 2016
The Potential of Human Stem Cells for the Study and Treatment of Glaucoma
Author(s): Chamling X (1), Sluch VM (2), Zack DJ (2) 1 Department of Ophthalmology Wilmer Eye Institute, Johns Hopkins University School of...
May 31, 2016
GluA2 Trafficking Is Involved in Apoptosis of Retinal Ganglion Cells Induced by Activation of EphB/EphrinB Reverse Signaling in a Rat Chronic Ocular Hypertension Model
Author(s): Dong LD (1), Gao F (2), Wang XH (1), Miao Y (1), Wang SY (1), Wu Y (1), Li F (1), Wu J (2), Cheng XL (3), Sun XH (2), Yang XL (1), Wang...
May 31, 2016
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In patients with glaucoma who require treatment for age-related macular degeneration or diabetic macular oedema, aflibercept may be a better choice of therapy than ranibizumab, as it is less likely to result in a delayed and sustained rise in IOP
The science behind the tip Anti - VEGF injection therapy for age-related macular degeneration or diabetic macular oedema may result in a delayed...
April 30, 2016
The Pathogenesis of Raised Intraocular Pressure in Uveitis
Author(s): Baneke AJ (1), Lim KS (1), Stanford M (1) 1 a Department of Ophthalmology , St Thomas' Hospital, Guy's and St Thomas' NHS Trust , London...
April 30, 2016
Transplanted neurons integrate into adult retinas and respond to light
Author(s): Venugopalan P (1,2), Wang Y (2), Nguyen T (2), Huang A (2), Muller KJ (1,3), Goldberg JL (1,2,4) 1 Neuroscience Program, University of...
April 30, 2016
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Beware of the patient who presents with acute angle closure and transient myopia, as this may occur as an idiosyncratic side effect of oral sulfonamides
The science behind the tip The normal mechanism of angle closure is pupillary block, which is treated with a laser peripheral iridotomy (PI)....
March 31, 2016
Rate and Pattern of Rim Area Loss in Healthy and Progressing Glaucoma Eyes
Author(s): Hammel N (1), Belghith A (1), Bowd C (1), Medeiros FA (1), Sharpsten L (1), Mendoza N (1), Tatham AJ (1), Khachatryan N (1), Liebmann JM...
March 31, 2016
Retinal and Optic Nerve Damage is Associated with Early Glial Responses in an Experimental Autoimmune Glaucoma Model
Author(s): Noristani R (1), Kuehn S (1), Stute G (1), Reinehr S (1), Stellbogen M (1), Dick HB (1), Joachim SC (2) 1 Experimental Eye Research...
March 31, 2016
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If a choroidal effusion develops after surgery in a patient with nanophthalmos then a partial thickness lamellar sclerectomy is an effective therapeutic option
The science behind the tip Raised IOP and secondary glaucoma are common late consequences of nanophthalmos (axial length less than 20mm)....
January 31, 2016
Microstructure of Peripapillary Atrophy and Subsequent Visual Field Progression in Treated Primary Open-Angle Glaucoma
Author(s): Yamada H (1), Akagi T (2), Nakanishi H (1), Ikeda HO (1), Kimura Y (1), Suda K (1), Hasegawa T (1), Yoshikawa M (1), Iida Y (1),...
January 31, 2016