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Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization
Purpose: Glaucoma is the primary cause of permanent vision loss worldwide. However, the...
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Quality of Life and Primary Open-Angle Glaucoma in the Ocular Hypertension Treatment Study
Importance: If preperimetric glaucoma reduces patient-reported vision-related quality of life...
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Fatal beauty: which cosmetics are your glaucoma patients using?
Colorism refers to the difference in social treatment between light-skinned and dark-skinned...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Successful optic nerve regeneration in the senescent zebrafish despite age-related decline of cell intrinsic and extrinsic response processes
Author(s): Van Houcke J (1), Bollaerts I (1), Geeraerts E (1), Davis B (2), Beckers A (1), Van Hove I (1), Lemmens K (1), De Groef L (3), Moons L...
October 31, 2017
Mitochondrial dysfunction in ocular disease: Focus on glaucoma
Author(s): Kamel K (1), Farrell M (2), O'Brien C (3) 1 Institute of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland. 2...
September 30, 2017
Interleukin-6 Deficiency Attenuates Retinal Ganglion Cell Axonopathy and Glaucoma-Related Vision Loss
Author(s): 1 Neuroscience Graduate Program, Vanderbilt UniversityNashville, TN, United States. 2 Department of Ophthalmology and Visual Sciences,...
July 31, 2017
Regulation of intraocular pressure by microRNA cluster miR-143/145
Author(s): Li X (1,2), Zhao F (3,4), Xin M (5), Li G (6), Luna C (6), Li G (1), Zhou Q (4), He Y (2), Yu B (4), Olson E (7), Gonzalez P (6), Wang S...
June 30, 2017
Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma
Author(s): Zhu W (1), Jain A (2), Gramlich OW (3), Tucker BA (3), Sheffield VC (4), Kuehn MH (1) 1 Department of Ophthalmology and Visual Sciences,...
May 31, 2017
The pressure-induced deformation response of the human lamina cribrosa: Analysis of regional variations
Author(s): Midgett DE (1), Pease ME (2), Jefferys JL (2), Patel M (3), Franck C (3), Quigley HA (2), Nguyen TD (4) 1 Department of Mechanical...
March 31, 2017
New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics
Author(s): Springelkamp H (1,2), Iglesias AI, Mishra A (3,4), Höhn R (5,6), Wojciechowski R, Khawaja AP (7), Nag A (8), Wang YX (9,10), Wang JJ...
February 28, 2017
Lamina cribrosa in glaucoma
Author(s): Downs JC (1), Girkin CA 1 Department of Ophthalmology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA....
January 31, 2017
The neuroprotective effect of latanoprost acts via klotho-mediated suppression of calpain activation after optic nerve transection
Author(s): Yamamoto K (1), Sato K (1,2), Yukita M (1), Yasuda M (1), Omodaka K (1,2), Ryu M (1), Fujita K (3), Nishiguchi KM (4), Machida S (5,6),...
December 31, 2016
Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine
Author(s): Fini ME (1), Schwartz SG (2), Gao X (3), Jeong S (4), Patel N (5), Itakura T (6), Price MO (7), Price FW Jr (8), Varma R (9), Stamer WD...
November 30, 2016
Assessing the Association of Mitochondrial Genetic Variation With Primary Open-Angle Glaucoma Using Gene-Set Analyses
Author(s): Khawaja AP(1), Cooke Bailey JN(2), Kang JH(3), Allingham RR(4), Hauser MA(5), Brilliant M(6), Budenz DL(7), Christen WG(8), Fingert...
October 31, 2016
Glaucoma related Proteomic Alterations in Human Retina Samples
Author(s): Funke S (1), Perumal N (1), Beck S (1), Gabel-Scheurich S (1), Schmelter C (1), Teister J (1), Gerbig C (1), Gramlich OW (1,2), Pfeiffer...
September 30, 2016
Predegenerated Schwann cells-a novel prospect for cell therapy for glaucoma: neuroprotection, neuroregeneration and neuroplasticity
Author(s): Smedowski A (1,2,3), Liu X (4), Pietrucha-Dutczak M (1), Matuszek I (1), Varjosalo M (4), Lewin-Kowalik J (1) 1 Chair and Department of...
July 31, 2016
Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma
Author(s): Vithana EN (1), Khor CC, Qiao C, Nongpiur ME, George R, Chen LJ, Do T, Abu-Amero K, Huang CK, Low S, Tajudin LS, Perera SA, Cheng CY, Xu...
June 30, 2016
The Potential of Human Stem Cells for the Study and Treatment of Glaucoma
Author(s): Chamling X (1), Sluch VM (2), Zack DJ (2) 1 Department of Ophthalmology Wilmer Eye Institute, Johns Hopkins University School of...
May 31, 2016
GluA2 Trafficking Is Involved in Apoptosis of Retinal Ganglion Cells Induced by Activation of EphB/EphrinB Reverse Signaling in a Rat Chronic Ocular Hypertension Model
Author(s): Dong LD (1), Gao F (2), Wang XH (1), Miao Y (1), Wang SY (1), Wu Y (1), Li F (1), Wu J (2), Cheng XL (3), Sun XH (2), Yang XL (1), Wang...
May 31, 2016
Transplanted neurons integrate into adult retinas and respond to light
Author(s): Venugopalan P (1,2), Wang Y (2), Nguyen T (2), Huang A (2), Muller KJ (1,3), Goldberg JL (1,2,4) 1 Neuroscience Program, University of...
April 30, 2016
Retinal and Optic Nerve Damage is Associated with Early Glial Responses in an Experimental Autoimmune Glaucoma Model
Author(s): Noristani R (1), Kuehn S (1), Stute G (1), Reinehr S (1), Stellbogen M (1), Dick HB (1), Joachim SC (2) 1 Experimental Eye Research...
March 31, 2016
Decreased Energy Capacity and Increased Autophagic Activity in Optic Nerve Axons With Defective Anterograde Transport
Author(s): Kleesattel D, Crish SD, Inman DM PURPOSE: Autophagy is a critical process, compromised in neurodegenerative disease, by which terminally...
January 31, 2016
Measurement of Systemic Mitochondrial Function in Advanced Primary Open-Angle Glaucoma and Leber Hereditary Optic Neuropathy
Author(s): Van Bergen NJ (1), Crowston JG (1), Craig JE (2), Burdon KP (2), Kearns LS (1), Sharma S (2), Hewitt AW (1), Mackey DA (3), Trounce IA...
December 31, 2015
Intraocular pressure reduction and neuroprotection conferred by bone marrow-derived mesenchymal stem cells in an animal model of glaucoma
Author(s): Roubeix C (1,2,3), Godefroy D (4,5,6), Mias C (7), Sapienza A (8,9,10), Riancho L (11,12,13), Degardin J (14,15,16), Fradot V...
November 30, 2015
Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation
Author(s): Cueva Vargas JL (1), Osswald IK (2), Unsain N (3), Aurousseau MR (2), Barker PA (3), Bowie D (2), Di Polo A (4) 1 Department of...
October 31, 2015
In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS
Author(s): Takihara Y (1), Inatani M (2), Eto K (3), Inoue T (4), Kreymerman A (5), Miyake S (6), Ueno S (7), Nagaya M (7), Nakanishi A (7), Iwao K...
September 30, 2015
Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and Rat
Author(s): Bogner B (1), Boye SL (2), Min SH (2), Peterson JJ (2), Ruan Q (2), Zhang Z (1), Reitsamer HA (1), Hauswirth WW (2), Boye SE (2) 1...
July 31, 2015
In vivo dynamics of retinal microglial activation during neurodegeneration: confocal ophthalmoscopic imaging and cell morphometry in mouse glaucoma
Author(s): Bosco A (1), Romero CO (2), Ambati BK (3), Vetter ML (2) 1 Department of Neurobiology & Anatomy, University of Utah;...
June 30, 2015