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Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization
Purpose: Glaucoma is the primary cause of permanent vision loss worldwide. However, the...
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Quality of Life and Primary Open-Angle Glaucoma in the Ocular Hypertension Treatment Study
Importance: If preperimetric glaucoma reduces patient-reported vision-related quality of life...
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Fatal beauty: which cosmetics are your glaucoma patients using?
Colorism refers to the difference in social treatment between light-skinned and dark-skinned...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Protective effect of lipoic acid against oxidative stress is mediated by Keap1/Nrf2-dependent heme oxygenase-1 induction in the RGC-5 cell line
Author(s): Koriyama Y, Nakayama Y, Matsugo S, Kato S. Department of Molecular Neurobiology, Graduate School of Medicine. Electronic address:...
February 28, 2013
Balance control in glaucoma
Author(s): Kotecha A, Richardson G, Chopra R, Fahy RT, Garway-Heath DF, Rubin GS Department of Visual Neuroscience, University College London (UCL)...
January 31, 2013
A new safety concern for glaucoma treatment demonstrated by mass spectrometry imaging of benzalkonium chloride distribution in the eye, an experimental study in rabbits
Author(s): Brignole-Baudouin F, Desbenoit N, Hamm G, Liang H, Both JP, Brunelle A, Fournier I, Guerineau V, Legouffe R, Stauber J, Touboul D,...
January 31, 2013
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Intravitreal steroids should be used with caution in patients with glaucoma
The Science behind the Tip In recent years it has become common practice to inject steroids into the vitreous to reduce macular oedema or ocular...
December 31, 2012
Factors that influence standard automated perimetry test results in glaucoma: test reliability, technician experience, time of day, and season
Author(s): Junoy Montolio FG, Wesselink C, Gordijn M, Jansonius NM Department of Ophthalmology, University Medical Center Groningen, University of...
December 31, 2012
Dorsomedial/Perifornical hypothalamic stimulation increases intraocular pressure, intracranial pressure, and the translaminar pressure gradient
Author(s): Samuels BC, Hammes NM, Johnson PL, Shekhar A, McKinnon SJ, Allingham RR Eugene and Marilyn Glick Eye Institute, the. PURPOSE:...
December 31, 2012
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Long-term application of benzalkonium chloride increases the risk of filtration surgery failure
The Science behind the Tip Glaucoma medication solutions usually contain the preservative benzalkonium chloride (BAK) in concentrations varying...
November 30, 2012
Retinal Vessel Caliber Is Associated with the 10-year Incidence of Glaucoma: The Blue Mountains Eye Study
Author(s): Kawasaki R, Wang JJ, Rochtchina E, Lee AJ, Wong TY, Mitchell P. Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital,...
November 30, 2012
Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma
Author(s): Vithana EN, Khor CC, Qiao C, Nongpiur ME, George R, Chen LJ, Do T, Abu-Amero K, Huang CK, Low S, Tajudin LS, Perera SA, Cheng CY, Xu L,...
November 30, 2012
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In patients with pseudoexfoliation glaucoma, phacoemulsification with IOL implantation can result in a late, sustained reduction in intraocular pressure
The Science behind the Tip Raised intraocular pressure (IOP) in an eye with pseudoexfoliation syndrome results from pigment and exfoliation...
October 31, 2012
Longitudinal effect of topical antiglaucoma medications on central corneal thickness
Author(s): Viswanathan D, Goldberg I, Graham SL Australian School of Advanced Medicine, Macquarie University, Sydney, Australia. BACKGROUND: To...
October 31, 2012
Intraocular pressure magnitude and variability as predictors of rates of structural change in non-human primate experimental glaucoma
Author(s): Gardiner SK, Fortune B, Wang L, Downs JC, Burgoyne CF Devers Eye Institute, Legacy Health, 1225 NE 2nd Ave., Portland, OR 97232, USA....
October 31, 2012
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Topical carbonic anhydrase inhibitors can cause damage in corneas with severe endothelial dysfunction
The Science behind the Tip The enzyme carbonic anhydrase is present in the corneal endothelium where it is involved in fluid transport (1). It thus...
September 30, 2012
Practical landmarks for visual field disability in glaucoma
Author(s): Saunders LJ, Russell RA, Crabb DP. City University London, London, UK. BACKGROUND/AIMS: To assess whether mean deviation (MD) from...
September 30, 2012
siRNA Silencing of Gene Expression in Trabecular Meshwork: RhoA siRNA Reduces IOP in Mice
Author(s): Liu Q, Wu K, Qiu X, Yang Y, Lin X, Yu M Few reports described efficient transfection in the trabecular meshwork (TM) in vivo. In the...
September 30, 2012
The Relationship Between Statin Use and Open-Angle Glaucoma
Author(s): Stein JD, Newman-Casey PA, Talwar N, Nan B, Richards JE, Musch DC. Department of Ophthalmology and Visual Sciences, University of...
July 31, 2012
Structural and functional abnormalities of retinal ganglion cells measured in vivo at the onset of optic nerve head surface change in experimental glaucoma
Author(s): Fortune B, Burgoyne CF, Cull GA, Reynaud J, Wang L. Devers Eye Institute, Discoveries in Sight Research Laboratories, Legacy Research...
July 31, 2012
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In patients with progressive normal tension glaucoma, the use of topical brimonidine may help to preserve visual function
The Science behind the Tip A recent study has shown that visual function is more likely to be preserved with brimonidine 2% than with timolol 0.5%...
June 30, 2012
Do patients with glaucoma have difficulty recognising faces?
Author(s): Glen FC, Crabb DP, Smith ND, Burton R, Garway-Heath DF. Department of Optometry and Visual Science, City University London, Northampton...
June 30, 2012
IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma
Author(s): Gallego BI, Salazar JJ, de Hoz R, Rojas B, Ramírez AI, Salinas-Navarro M, Ortín-Martínez A, Valiente-Soriano FJ, Avilés-Trigueros M,...
June 30, 2012
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A dry eye can hamper visual field test interpretation
The Science behind the Tip During visual field (VF) testing the cornea of patients with severe dry eye condition can get dry to such an extent as...
May 31, 2012
Prevalence of cognitive impairment, depression, and anxiety symptoms among older adults with glaucoma
Author(s): Yochim BP, Mueller AE, Kane KD, Kahook MY. Department of Psychology, University of Colorado at Colorado Springs, Colorado Springs...
May 31, 2012
JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death
Author(s): Fernandes KA, Harder JM, Fornarola LB, Freeman RS, Clark AF, Pang IH, John SW, Libby RT. Flaum Eye Institute, University of Rochester...
May 31, 2012
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Laser peripheral iridotomy can reduce the intraocular pressure in pigment dispersion syndrome, but may not prevent glaucoma
The Science behind the Tip Nd-YAG laser peripheral iridotomy (PI) eliminates the reverse pressure gradient and intermittent posterior bowing of the...
April 30, 2012
The effect of thin, thick, and normal corneas on Goldmann intraocular pressure measurements and correction formulae in individual eyes
Author(s): Park SJ, Ang GS, Nicholas S, Wells AP. Eye Department, Wellington Hospital, Capital and Coast District Health Board, Wellington, New...
April 30, 2012