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  • Exfoliation SIG Corner

    SIG Corner Editor: Hana Abouzeid Chair: Gabor Hollo Co-chair: Anastasios G. Konstas The goal of this SIG is to increase ophthalmologists’ knowledge...

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    Exfoliation SIG Corner

    Exfoliation SIG Corner

    SIG Corner Editor: Hana Abouzeid Chair: Gabor Hollo Co-chair: Anastasios G. Konstas The goal of...

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  • IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

    Purpose: Expansion of the suprachoroidal space (SCS) by a hydrogel injection has been shown to reduce intraocular pressure (IOP) in rabbits as a...

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    IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

    IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

    Purpose: Expansion of the suprachoroidal space (SCS) by a hydrogel injection has been shown to...

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  • Relationship between Intraocular Pressure Fluctuation and Visual Field Progression Rates in the United Kingdom Glaucoma Treatment Study

    Purpose: To investigate whether intraocular pressure (IOP) fluctuation is associated independently with the rate of visual field (VF) progression...

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    Relationship between Intraocular Pressure Fluctuation and Visual Field Progression Rates in the United Kingdom Glaucoma Treatment Study

    Relationship between Intraocular Pressure Fluctuation and Visual Field Progression Rates in the United Kingdom Glaucoma Treatment Study

    Purpose: To investigate whether intraocular pressure (IOP) fluctuation is associated...

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  • Using anterior segment OCT to risk-stratify primary angle closure suspects

    Gonioscopy is the clinical standard for detecting patients at risk for primary angle closure glaucoma (PACG). However, anterior chamber angle...

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    Using anterior segment OCT to risk-stratify primary angle closure suspects

    Using anterior segment OCT to risk-stratify primary angle closure suspects

    Gonioscopy is the clinical standard for detecting patients at risk for primary angle closure...

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  • The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with many individuals living with more than one illness....

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    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    The relationship between multiple deprivation and severity of glaucoma at diagnosis

    BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...

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  • Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee (4), Sung Ryul Shim (5), Ahnul Ha (6) 1 Department...

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    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis

    Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...

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  • Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG is to further the promotion of knowledge about the...

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    Angle Closure SIG

    Angle Closure SIG

    SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...

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  • Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather Eliassen (3,4,5,6), Lisa Frueh (3), Clary B Clish (7),...

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    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

    Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...

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  • Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to misinterpretation of disease progression. Studies have...

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    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients

    Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...

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  • Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês Silva (1), João Barbosa-Breda (1,2,3), Joana Araújo...

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    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists

    Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...

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  • Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which can occur with drugs such as topiramate. The...

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    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure

    The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...

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  • Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...

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    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery

    The accelerated development of cataract is frequently seen in the years following glaucoma...

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The effect of positional changes on intraocular pressure during sleep in patients with and without glaucoma

Clinical paper of the month

The effect of positional changes on intraocular pressure during sleep in patients with and without glaucoma

Author(s): Lazzaro EC(1), Mallick A, Singh M, Reich I, Elmann S, Stefanov DG, Lazzaro DR. 1 Department of Ophthalmology - Scientific Computing...

July 31, 2014

Optic Nerve Head Blood Flow Response to Reduced Ocular Perfusion Pressure by Alteration of Either the Blood Pressure or Intraocular Pressure

Experimental Paper of the Month

Optic Nerve Head Blood Flow Response to Reduced Ocular Perfusion Pressure by Alteration of Either the Blood Pressure or Intraocular Pressure

Author(s): Wang L(1), Cull GA, Fortune B. 1 Devers Eye Institute, Legacy Research Institute, Portland, OR, USA. ABSTRACT PURPOSE: To test the...

July 31, 2014

Patients with pseudoexfoliation syndrome often have loss of hearing and should be referred for audiometry

Tip of the month

Patients with pseudoexfoliation syndrome often have loss of hearing and should be referred for audiometry

The Science behind the Tip Pseudoexfoliation syndrome is an important cause of glaucoma. It has been known for many years that pseudoexfoliation...

June 30, 2014

Three-year Treatment Outcomes in the Ahmed Baerveldt Comparison Study

Clinical paper of the month

Three-year Treatment Outcomes in the Ahmed Baerveldt Comparison Study

Author(s): Barton K(1), Feuer WJ(2), Budenz DL(3), Schiffman J(2), Costa VP(4), Godfrey DG(5), Buys YM(6); Ahmed Baerveldt Comparison Study Group 1...

June 30, 2014

Discovery and Functional Annotation of SIX6 Variants in Primary Open-Angle Glaucoma

Experimental Paper of the Month

Discovery and Functional Annotation of SIX6 Variants in Primary Open-Angle Glaucoma

Author(s): Ulmer Carnes M(1), Liu YP(2), Allingham RR(3), Whigham BT(3), Havens S(3), Garrett ME(1), Qiao C(4); NEIGHBORHOOD Consortium...

June 30, 2014

Dietary supplementation and glaucoma

Tip of the month

Dietary supplementation and glaucoma

The Science behind the Tip Dietary supplements belong to the broad group of complementary and alternative medicine (CAM). A recent survey in Canada...

May 31, 2014

Effect of Focal Lamina Cribrosa Defect on Glaucomatous Visual Field Progression

Clinical paper of the month

Effect of Focal Lamina Cribrosa Defect on Glaucomatous Visual Field Progression

Author(s): Faridi OS(1), Park SC(2), Kabadi R(3), Su D(1), De Moraes CG(4), Liebmann JM(4), Ritch R(5) 1 Moise and Chella Safra Advanced Ocular...

May 31, 2014

MMPs in the neuroretina and optic nerve: modulators of glaucoma pathogenesis and repair?

Experimental Paper of the Month

MMPs in the neuroretina and optic nerve: modulators of glaucoma pathogenesis and repair?

Author(s): De Groef L(1), Van Hove I, Dekeyster E, Stalmans I, Moons L. 1 Laboratory of Neural Circuit Development and Regeneration, Animal...

May 31, 2014

Patients with pigmentary glaucoma respond well to laser trabeculoplasty, but steps must be taken to reduce the risk of the IOP spike that may occur immediately after the laser treatment

Tip of the month

Patients with pigmentary glaucoma respond well to laser trabeculoplasty, but steps must be taken to reduce the risk of the IOP spike that may occur immediately after the laser treatment

The Science behind the Tip Argon or selective laser trabeculoplasty (LT) is an established therapeutic option in the treatment of patients with...

April 30, 2014

Intraocular pressure fluctuation and glaucoma progression: what do we know?

Clinical paper of the month

Intraocular pressure fluctuation and glaucoma progression: what do we know?

Author(s): Leidl MC(1), Choi CJ, Syed ZA, Melki SA. 1 Nassau University Medical Center, East Meadow, New York, USA. While mean intraocular pressure...

April 30, 2014

γ-Synuclein Antibodies Have Neuroprotective Potential on Neuroretinal Cells via Proteins of the Mitochondrial Apoptosis Pathway

Experimental Paper of the Month

γ-Synuclein Antibodies Have Neuroprotective Potential on Neuroretinal Cells via Proteins of the Mitochondrial Apoptosis Pathway

Author(s): Wilding C, Bell K, Beck S, Funke S, Pfeiffer N, Grus FH. Experimental Ophthalmology, Department of Ophthalmology, Medical Center of the...

April 30, 2014

It is important that glaucoma patients at risk of end-of-life visual impairment should be identified and treated accordingly

Tip of the month

It is important that glaucoma patients at risk of end-of-life visual impairment should be identified and treated accordingly

The Science behind the Tip The ultimate outcome measure of glaucoma treatment is visual impairment and blindness at the time of death. Based on a...

March 31, 2014

The Potential Association Between Postmenopausal Hormone Use and Primary Open-Angle Glaucoma

Clinical paper of the month

The Potential Association Between Postmenopausal Hormone Use and Primary Open-Angle Glaucoma

Author(s): Newman-Casey PA(1), Talwar N(1), Nan B(2), Musch DC(3), Pasquale LR(4), Stein JD(5). 1 Department of Ophthalmology and Visual Sciences,...

March 31, 2014

Mitochondrial DNA Variant Discovery in Normal-Tension Glaucoma Patients by Next-Generation Sequencing

Experimental Paper of the Month

Mitochondrial DNA Variant Discovery in Normal-Tension Glaucoma Patients by Next-Generation Sequencing

Author(s): Jeoung JW(1), Seong MW, Park SS, Kim DM, Kim SH, Park KH. 1 Department of Ophthalmology, Seoul National University Hospital, Seoul,...

March 31, 2014

Perimetry should be undertaken soon after phacoemulsification and multifocal IOL implantation in patients with glaucoma, in order to establish new baseline parameters

Tip of the month

Perimetry should be undertaken soon after phacoemulsification and multifocal IOL implantation in patients with glaucoma, in order to establish new baseline parameters

The Science behind the Tip To determine change in visual function in patients with glaucoma, regular visual field testing is undertaken using...

February 28, 2014

Emerging novel roles of neuropeptide Y in the retina: From neuromodulation to neuroprotection

Experimental Paper of the Month

Emerging novel roles of neuropeptide Y in the retina: From neuromodulation to neuroprotection

Author(s): Santos-Carvalho A (1), Alvaro AR (2), Martins J (3), Ambrósio AF (4), Cavadas C (5) Neuropeptide Y (NPY) and NPY receptors are widely...

February 28, 2014

The early diagnosis of glaucoma and early detection of glaucoma progression should be enhanced by the use of spectral domain OCT measurement of the neuro retinal rim

Tip of the month

The early diagnosis of glaucoma and early detection of glaucoma progression should be enhanced by the use of spectral domain OCT measurement of the neuro retinal rim

The Science behind the Tip Recent studies using spectral domain ocular coherence tomography (SD OCT) measurement of the optic disc margin show that...

January 31, 2014

The 5-Year Incidence of Bleb-Related Infection and Its Risk Factors after Filtering Surgeries with Adjunctive Mitomycin C: Collaborative Bleb-Related Infection Incidence and Treatment Study 2

Clinical paper of the month

The 5-Year Incidence of Bleb-Related Infection and Its Risk Factors after Filtering Surgeries with Adjunctive Mitomycin C: Collaborative Bleb-Related Infection Incidence and Treatment Study 2

Author(s): Yamamoto T (1), Sawada A (2), Mayama C (3), Araie M (3), Ohkubo S (4), Sugiyama K4, Kuwayama Y (5); The Collaborative Bleb-Related...

January 31, 2014

Relationship between Preferred Sleeping Position and Asymmetric Visual-field Loss in Open-angle Glaucoma Patients

Clinical paper of the month

Relationship between Preferred Sleeping Position and Asymmetric Visual-field Loss in Open-angle Glaucoma Patients

Author(s): Kim KN(1), Jeoung JW(2), Park KH(3), Kim DM(4), Ritch R(5) 1 Department of Ophthalmology, Chungnam National University Hospital,...

January 31, 2014

Regulation of Plasticity and Fibrogenic Activity of Trabecular Meshwork Cells by Rho GTPase Signaling

Experimental Paper of the Month

Regulation of Plasticity and Fibrogenic Activity of Trabecular Meshwork Cells by Rho GTPase Signaling

Author(s): Pattabiraman PP, Maddala R, Rao PV. Department of Ophthalmology, Duke University School of Medicine, Durham, NC, 27710. Glaucoma, a...

January 31, 2014

Does optic nerve head surface topography change prior to loss of retinal nerve fiber layer thickness: a test of the site of injury hypothesis in experimental glaucoma

Clinical paper of the month

Does optic nerve head surface topography change prior to loss of retinal nerve fiber layer thickness: a test of the site of injury hypothesis in experimental glaucoma

Author(s): Fortune B, Reynaud J, Wang L, Burgoyne CF. Discoveries in Sight Research Laboratories, Devers Eye Institute, and Legacy Research...

December 31, 2013

Anti-Connective Tissue Growth Factor Antibody Treatment Reduces Extracellular Matrix production in Trabecular Meshwork and Lamina Cribrosa cells

Experimental Paper of the Month

Anti-Connective Tissue Growth Factor Antibody Treatment Reduces Extracellular Matrix production in Trabecular Meshwork and Lamina Cribrosa cells

Author(s): Wallace DM, Clark AF, Lipson K, Andrews D, Crean J, O'Brien CJ. PURPOSE: We have previously demonstrated elevated levels of Connective...

December 31, 2013

Consider using preservative-free topical medication in patients with ocular surface disease

Tip of the month

Consider using preservative-free topical medication in patients with ocular surface disease

The Science behind the Tip Many glaucoma drops contain a preservative agent to minimise the risk of microbial contamination. Benzalconium chloride,...

November 30, 2013

Cataract surgery after trabeculectomy increases the risk of bleb failure and this risk is increased if the time between trabeculectomy and cataract surgery is short

Tip of the month

Cataract surgery after trabeculectomy increases the risk of bleb failure and this risk is increased if the time between trabeculectomy and cataract surgery is short

The Science behind the Tip Trabeculectomy surgery is a recognised risk factor for the subsequent development of cataract. Phacoemulsification with...

November 30, 2013

Pathogenesis and clinical implications of optic disk hemorrhage in glaucoma

Clinical paper of the month

Pathogenesis and clinical implications of optic disk hemorrhage in glaucoma

Author(s): Suh MH, Park KH. Department of Ophthalmology, Haeundae Paik Hospital, Busan, Korea; Department of Ophthalmology, Inje University College...

November 30, 2013