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The scleral spur
The scleral spur is a ring-shaped structure, primarily collagen with 5% elastin (1), providing...
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Neuroprotection in Glaucoma: Investigational, Complementary to IOP-Lowering
Tip: Neuroprotection in glaucoma is investigational and may be considered only as an adjunct,...
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Evaluating High Intraocular Pressure Criteria for Failure in Glaucoma Surgery: Impact on Estimated Success and Visual Field Rates
Purpose: Review high intraocular pressure (IOP) thresholds used as failure criteria in glaucoma...
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Gonioscopy is always essential
Angle closure is defined by iridotrabecular contact of ≥180° (1) and the presence or development...
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Association of Blood Pressure and Retinal Nerve Fiber Layer Rates of Thinning in Patients with Moderate to Advanced Glaucoma
Objective: To investigate the influence of baseline blood pressure (BP) on retinal nerve fiber...
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Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use - A Prospective Study
Purpose: To investigate the correlations between aqueous humor total antioxidant capacity (TAC)...
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Care Delivery
SIG Corner Editor: Hana Abouzeid Chair: Anton B. Hommer Co-chair: Gabor Hollo Update on ongoing...
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Comparative Study of Early Safety and Effectiveness Outcomes of the PreserFlo MicroShunt with and without an Intraluminal Suture Stent
Objective: To assess the early safety and effectiveness outcomes of the PreserFlo MicroShunt with...
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Iris Crypts Could Reduce the Chance of Angle Closure: A Computational Biomechanics Study Derived From Clinical and Human Iris Data
Purpose: To investigate the effect of crypts during pupil constriction and dilation on the...
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Glaucoma drainage devices - Is the Paul glaucoma implant suitable for children with glaucoma?
Only a few studies exist on the Paul glaucoma device in children with glaucoma. Compared to Ahmed...
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Comparison of Methods to Deliver Mitomycin C in Trabeculectomy Surgery: a Systematic Review and Meta-analysis
Purpose: Compare different methods to deliver Mitomycin C (MMC) in trabeculectomy surgery....
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Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use - A Prospective Study
Purpose: To investigate the correlations between aqueous humor total antioxidant capacity (TAC)...
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Early detection of hypotony maculopathy is essential, as permanent chorioretinal changes and poor visual outcomes will occur without rapid surgical intervention
The science behind the tip Hypotony maculopathy is an uncommon but serious late complication of glaucoma filtration surgery, particularly when an...
May 31, 2016
Diabetes, Triglyceride Levels, and Other Risk Factors for Glaucoma in the National Health and Nutrition Examination Survey 2005-2008
Author(s): Ko F (1), Boland MV (2), Gupta P (3), Gadkaree SK (4), Vitale S (5), Guallar E (6), Zhao D (6), Friedman DS (7) 1 Glaucoma, Moorfields...
May 31, 2016
The Potential of Human Stem Cells for the Study and Treatment of Glaucoma
Author(s): Chamling X (1), Sluch VM (2), Zack DJ (2) 1 Department of Ophthalmology Wilmer Eye Institute, Johns Hopkins University School of...
May 31, 2016
GluA2 Trafficking Is Involved in Apoptosis of Retinal Ganglion Cells Induced by Activation of EphB/EphrinB Reverse Signaling in a Rat Chronic Ocular Hypertension Model
Author(s): Dong LD (1), Gao F (2), Wang XH (1), Miao Y (1), Wang SY (1), Wu Y (1), Li F (1), Wu J (2), Cheng XL (3), Sun XH (2), Yang XL (1), Wang...
May 31, 2016
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In patients with glaucoma who require treatment for age-related macular degeneration or diabetic macular oedema, aflibercept may be a better choice of therapy than ranibizumab, as it is less likely to result in a delayed and sustained rise in IOP
The science behind the tip Anti - VEGF injection therapy for age-related macular degeneration or diabetic macular oedema may result in a delayed...
April 30, 2016
The Pathogenesis of Raised Intraocular Pressure in Uveitis
Author(s): Baneke AJ (1), Lim KS (1), Stanford M (1) 1 a Department of Ophthalmology , St Thomas' Hospital, Guy's and St Thomas' NHS Trust , London...
April 30, 2016
Transplanted neurons integrate into adult retinas and respond to light
Author(s): Venugopalan P (1,2), Wang Y (2), Nguyen T (2), Huang A (2), Muller KJ (1,3), Goldberg JL (1,2,4) 1 Neuroscience Program, University of...
April 30, 2016
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Beware of the patient who presents with acute angle closure and transient myopia, as this may occur as an idiosyncratic side effect of oral sulfonamides
The science behind the tip The normal mechanism of angle closure is pupillary block, which is treated with a laser peripheral iridotomy (PI)....
March 31, 2016
Rate and Pattern of Rim Area Loss in Healthy and Progressing Glaucoma Eyes
Author(s): Hammel N (1), Belghith A (1), Bowd C (1), Medeiros FA (1), Sharpsten L (1), Mendoza N (1), Tatham AJ (1), Khachatryan N (1), Liebmann JM...
March 31, 2016
Retinal and Optic Nerve Damage is Associated with Early Glial Responses in an Experimental Autoimmune Glaucoma Model
Author(s): Noristani R (1), Kuehn S (1), Stute G (1), Reinehr S (1), Stellbogen M (1), Dick HB (1), Joachim SC (2) 1 Experimental Eye Research...
March 31, 2016
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If a choroidal effusion develops after surgery in a patient with nanophthalmos then a partial thickness lamellar sclerectomy is an effective therapeutic option
The science behind the tip Raised IOP and secondary glaucoma are common late consequences of nanophthalmos (axial length less than 20mm)....
January 31, 2016
Microstructure of Peripapillary Atrophy and Subsequent Visual Field Progression in Treated Primary Open-Angle Glaucoma
Author(s): Yamada H (1), Akagi T (2), Nakanishi H (1), Ikeda HO (1), Kimura Y (1), Suda K (1), Hasegawa T (1), Yoshikawa M (1), Iida Y (1),...
January 31, 2016
Decreased Energy Capacity and Increased Autophagic Activity in Optic Nerve Axons With Defective Anterograde Transport
Author(s): Kleesattel D, Crish SD, Inman DM PURPOSE: Autophagy is a critical process, compromised in neurodegenerative disease, by which terminally...
January 31, 2016
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Patients with neovascular glaucoma secondary to ocular ischaemia syndrome need pan-retinal photocoagulation and urgent referral to a physician
The science behind the tip The cause of neovascular glaucoma in two thirds of patients is either proliferative diabetic retinopathy or an ischaemic...
December 31, 2015
Trabeculectomy Can Improve Long-Term Visual Function in Glaucoma
Author(s): Caprioli J (1), de Leon JM (2), Azarbod P (2), Chen A (2), Morales E (2), Nouri-Mahdavi K (2), Coleman A (2), Yu F (3), Afifi A (4) 1...
December 31, 2015
Measurement of Systemic Mitochondrial Function in Advanced Primary Open-Angle Glaucoma and Leber Hereditary Optic Neuropathy
Author(s): Van Bergen NJ (1), Crowston JG (1), Craig JE (2), Burdon KP (2), Kearns LS (1), Sharma S (2), Hewitt AW (1), Mackey DA (3), Trounce IA...
December 31, 2015
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Avoid the upper nasal quadrant when inserting an aqueous drainage implant, as it can result in acquired Brown syndrome
The science behind the tip Aqueous drainage tubes are commonly used in the surgical treatment of refractory glaucoma. New onset persistent diplopia...
November 30, 2015
Visual impairment and vision-related quality of life in the Early Manifest Glaucoma Trial after 20 years of follow-up
Author(s): Peters D (1), Heijl A (1), Brenner L (2), Bengtsson B (1) 1 Department of Ophthalmology, Skåne University Hospital, Lund University,...
November 30, 2015
Intraocular pressure reduction and neuroprotection conferred by bone marrow-derived mesenchymal stem cells in an animal model of glaucoma
Author(s): Roubeix C (1,2,3), Godefroy D (4,5,6), Mias C (7), Sapienza A (8,9,10), Riancho L (11,12,13), Degardin J (14,15,16), Fradot V...
November 30, 2015
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Artifacts in the SD-OCT images in a patient with glaucoma or suspected glaucoma may lead to an erroneous conclusion
The science behind the tip Structural measurements of the optic disc and retinal nerve fibre layer (RNFL) have become an indispensable tool in the...
October 31, 2015
Association between Platelet Function and Disc Hemorrhage in Patients with Normal Tension Glaucoma: A prospective cross-sectional study
Author(s): Shim SH (1), Kim JM (2), Woo HY (3), Shin KU (1), Koh JW (4), Park KH (5) 1 Department of Ophthalmology, Kangbuk Samsung Hospital,...
October 31, 2015
Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation
Author(s): Cueva Vargas JL (1), Osswald IK (2), Unsain N (3), Aurousseau MR (2), Barker PA (3), Bowie D (2), Di Polo A (4) 1 Department of...
October 31, 2015
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The ISNT rule is of limited benefit in differentiating early glaucoma from normal
The science behind the tip The ISNT rule states that a healthy optic disc has a characteristic configuration of the neuro-retinal rim; which is...
September 30, 2015
Patterns of Glaucoma Medication Adherence over Four Years of Follow-Up
Author(s): Newman-Casey PA (1), Blachley T (2), Lee PP (3), Heisler M (4), Farris KB (5), Stein JD (3) 1 Department of Ophthalmology and Visual...
September 30, 2015
In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS
Author(s): Takihara Y (1), Inatani M (2), Eto K (3), Inoue T (4), Kreymerman A (5), Miyake S (6), Ueno S (7), Nagaya M (7), Nakanishi A (7), Iwao K...
September 30, 2015