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Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization
Purpose: Glaucoma is the primary cause of permanent vision loss worldwide. However, the...
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Quality of Life and Primary Open-Angle Glaucoma in the Ocular Hypertension Treatment Study
Importance: If preperimetric glaucoma reduces patient-reported vision-related quality of life...
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Fatal beauty: which cosmetics are your glaucoma patients using?
Colorism refers to the difference in social treatment between light-skinned and dark-skinned...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Retinal Astrocytes and GABAergic Wide-Field Amacrine Cells Express PDGFRα: Connection to Retinal Ganglion Cell Neuroprotection by PDGF-AA
Author(s): Takahama S (1), Adetunji MO (1), Zhao T (2), Chen S2, Li W (2), Tomarev SI (1) 1 Section on Retinal Ganglion Cell Biology, Laboratory of...
November 30, 2017
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A patient who presents with raised intraocular pressure or glaucoma and distended episcleral veins in one eye needs to be investigated for a spontaneous carotid – cavernous fistula
The Science behind the Tip A carotid – cavernous sinus fistula is an abnormal vascular communication between the carotid artery system and the...
October 31, 2017
Peptides of the variable IgG domain as potential biomarker candidates in primary open-angle glaucoma (POAG)
Author(s): Schmelter C (1), Perumal N (1), Funke S (1), Bell K (1), Pfeiffer N (1), Grus FH (1) 1 Department of Experimental and Translational...
October 31, 2017
Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis
Author(s): Aschard H (1), Kang JH (2), Iglesias AI (3), Hysi P (4), Cooke Bailey JN (5,6), Khawaja AP (7), Allingham RR (8), Ashley-Koch A (9), Lee...
October 31, 2017
Successful optic nerve regeneration in the senescent zebrafish despite age-related decline of cell intrinsic and extrinsic response processes
Author(s): Van Houcke J (1), Bollaerts I (1), Geeraerts E (1), Davis B (2), Beckers A (1), Van Hove I (1), Lemmens K (1), De Groef L (3), Moons L...
October 31, 2017
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Glaucoma associated with congenital aniridia is difficult to treat, but tube-shunt drainage devices offer the best results
The Science behind the Tip Congenital aniridia is a rare bilateral developmental disorder which is inherited in an autosomal dominant fashion in...
September 30, 2017
Rates of glaucomatous visual field change after trabeculectomy
Author(s): Baril C (1), Vianna JR (1), Shuba LM (1), Rafuse PE (1), Chauhan BC (1), Nicolela MT (1) 1 Department of Ophthalmology and Visual...
September 30, 2017
Mitochondrial dysfunction in ocular disease: Focus on glaucoma
Author(s): Kamel K (1), Farrell M (2), O'Brien C (3) 1 Institute of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland. 2...
September 30, 2017
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In a young patient with acute congestive angle closure or recurrent angle closure in the presence of a patent laser iridotomy, the underlying cause is usually plateau iris configuration
The Science behind the Tip Plateau iris configuration is characterised by a closed anterior chamber angle in association with a flat iris plane and...
July 31, 2017
Risk Factors for Rapid Glaucoma Disease Progression
Author(s): Chan TCW (1), Bala C (2), Siu A (3), Wan F (3), White A (4) 1 University of Sydney, Sydney, Australia. 2 Macquarie University, Sydney,...
July 31, 2017
Interleukin-6 Deficiency Attenuates Retinal Ganglion Cell Axonopathy and Glaucoma-Related Vision Loss
Author(s): 1 Neuroscience Graduate Program, Vanderbilt UniversityNashville, TN, United States. 2 Department of Ophthalmology and Visual Sciences,...
July 31, 2017
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The chronic use of prostaglandin analogues may lead to a modest underestimation of IOP when measured by Goldmann applanation tonometry
The Science behind the Tip Corneal hysteresis is a biomechanical property of the cornea relating to its elasticity. The measurement of corneal...
June 30, 2017
Mitochondrial dysfunction in ocular disease: Focus on glaucoma
Author(s): Kamel K (1), Farrell M (2), O'Brien C (3) 1 Institute of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland. 2...
June 30, 2017
Regulation of intraocular pressure by microRNA cluster miR-143/145
Author(s): Li X (1,2), Zhao F (3,4), Xin M (5), Li G (6), Luna C (6), Li G (1), Zhou Q (4), He Y (2), Yu B (4), Olson E (7), Gonzalez P (6), Wang S...
June 30, 2017
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In a patient with glaucoma who has unexplained hair loss, stop topical beta-blocker treatment
The Science behind the Tip Beta adrenergic receptor blocking eye drops are often used to reduce the intraocular pressure. Because of absorption...
May 31, 2017
Neuroprotection for glaucoma: Requirements for clinical translation
Author(s): Levin LA (1), Crowe ME (2), Quigley HA (3); Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants 1...
May 31, 2017
Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma
Author(s): Zhu W (1), Jain A (2), Gramlich OW (3), Tucker BA (3), Sheffield VC (4), Kuehn MH (1) 1 Department of Ophthalmology and Visual Sciences,...
May 31, 2017
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Patients with normal tension glaucoma who develop a branch retinal vein occlusion should be monitored with greater care
The Science behind the Tip If a branch retinal vein occlusion (BRVO) occurs in a patient with normal tension glaucoma, it tends to occur in the eye...
April 30, 2017
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Visual function may improve after trabeculectomy in some adults with moderately advanced glaucoma
The Science behind the Tip We were taught that visual field loss from glaucoma is irreversible and that our interventions could at best, preserve...
March 31, 2017
The challenge of regenerative therapies for the optic nerve in glaucoma
Author(s): Calkins DJ (1), Pekny M (2), Cooper ML (3), Benowitz L (4); Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration...
March 31, 2017
The pressure-induced deformation response of the human lamina cribrosa: Analysis of regional variations
Author(s): Midgett DE (1), Pease ME (2), Jefferys JL (2), Patel M (3), Franck C (3), Quigley HA (2), Nguyen TD (4) 1 Department of Mechanical...
March 31, 2017
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The regular (and sometimes clandestine) application of periocular corticosteroid cream can induce glaucoma in susceptible individuals
The Science behind the Tip Steroid-induced ocular hypertension and glaucoma is typically associated with topical steroid therapy and presents with...
February 28, 2017
Posner-Schlossman Syndrome
Author(s): Megaw R (1), Agarwal PK (2) 1 Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of...
February 28, 2017
New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics
Author(s): Springelkamp H (1,2), Iglesias AI, Mishra A (3,4), Höhn R (5,6), Wojciechowski R, Khawaja AP (7), Nag A (8), Wang YX (9,10), Wang JJ...
February 28, 2017
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In patients with primary angle-closure glaucoma and primary angle closure with high intraocular pressure (IOP), there is a good evidence to support the use of clear lens extraction with intraocular lens implantation as initial treatment
The Science behind the Tip The standard treatment for primary angle-closure glaucoma (PACG) is laser peripheral iridotomy (PI) to open the drainage...
January 31, 2017