Start with monotherapy

The greatest reduction of IOP is obtained with PGAs, followed by non-selective β-blockers, Rho-kinase inhibitors, alpha-adrenergic agonists, selective β-blockers, and topical carbonic anhydrase inhibitors. IOP-lowering treatment efficacy depends on untreated IOP, with larger reductions in patients with higher untreated IOP levels. Uniocular drug trials may be useful to evaluate the efficacy of topical therapy.

EGS Guidelines, 6th Edition, Page 167

Pearls Manager: Nestor Ventura-Abreu