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F4H5 Alleviates Increased Outflow Resistance Induced by Emulsified Silicone Oil In Vitro
Purpose: The purpose of this study was to investigate the effect of emulsified silicone oil on...
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The scleral spur
The scleral spur is a ring-shaped structure, primarily collagen with 5% elastin (1), providing...
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Neuroprotection in Glaucoma: Investigational, Complementary to IOP-Lowering
Tip: Neuroprotection in glaucoma is investigational and may be considered only as an adjunct,...
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Evaluating High Intraocular Pressure Criteria for Failure in Glaucoma Surgery: Impact on Estimated Success and Visual Field Rates
Purpose: Review high intraocular pressure (IOP) thresholds used as failure criteria in glaucoma...
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Gonioscopy is always essential
Angle closure is defined by iridotrabecular contact of ≥180° (1) and the presence or development...
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Association of Blood Pressure and Retinal Nerve Fiber Layer Rates of Thinning in Patients with Moderate to Advanced Glaucoma
Objective: To investigate the influence of baseline blood pressure (BP) on retinal nerve fiber...
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Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use - A Prospective Study
Purpose: To investigate the correlations between aqueous humor total antioxidant capacity (TAC)...
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Care Delivery
SIG Corner Editor: Hana Abouzeid Chair: Anton B. Hommer Co-chair: Gabor Hollo Update on ongoing...
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Comparative Study of Early Safety and Effectiveness Outcomes of the PreserFlo MicroShunt with and without an Intraluminal Suture Stent
Objective: To assess the early safety and effectiveness outcomes of the PreserFlo MicroShunt with...
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Iris Crypts Could Reduce the Chance of Angle Closure: A Computational Biomechanics Study Derived From Clinical and Human Iris Data
Purpose: To investigate the effect of crypts during pupil constriction and dilation on the...
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Glaucoma drainage devices - Is the Paul glaucoma implant suitable for children with glaucoma?
Only a few studies exist on the Paul glaucoma device in children with glaucoma. Compared to Ahmed...
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Comparison of Methods to Deliver Mitomycin C in Trabeculectomy Surgery: a Systematic Review and Meta-analysis
Purpose: Compare different methods to deliver Mitomycin C (MMC) in trabeculectomy surgery....
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Laser trabeculoplasty
ALT and SLT have the same IOP-lowering efficacy. Laser trabeculoplasty is initially effective in 80 to 85% of treated eyes with a mean IOP...
February 19, 2026
Choosing wisely / Things to avoid
Do not use MIGS on a rapidly worsening patient. MIGS are mostly used to offer the opportunity to mildly lower the IOP and decrease medications in...
February 19, 2026
Influence of intraocular pressure on clinical decision-making in glaucoma management
Importance: Understanding of intraocular pressure (IOP) as a continuous risk factor for glaucoma has evolved over time, and IOP reduction is widely...
February 17, 2026
IOP control should not come at the expense of the ocular surface
Topical IOP-lowering medications are widely used and effective in glaucoma management, but long-term exposure—particularly to preserved, multi-drug...
February 17, 2026
Circulating eNAMPT in glaucoma: A semi-quantitative plasma analysis before and after nicotinamide supplementation
Purpose: Glaucoma is characterized by progressive retinal ganglion cell degeneration. Nicotinamide supplementation has demonstrated neuroprotective...
February 17, 2026
Start with monotherapy
The greatest reduction of IOP is obtained with PGAs, followed by non-selective β-blockers, Rho-kinase inhibitors, alpha-adrenergic agonists,...
January 21, 2026
Intraocular pressure and corneal thickness
Ophthalmologists should be aware that tonometry readings may substantially underestimate IOP in patients treated for the correction of myopia with...
January 21, 2026
Consider and address steroid response when indicating intravitreal corticosteroid therapy - especially in patients with high baseline IOP and in those with glaucoma.
A substantial proportion of patients who require intravitreal corticosteroid injections or implants have comorbid glaucoma or an increased risk of...
January 18, 2026
Prediction of repeatable glaucomatous visual field defects based on cluster characteristics.
Aim: This study evaluates if characteristics (eg, location, size, volume) of clusters of defects on an initial visual field (VF) test were...
January 18, 2026
Generative Artificial Intelligence for Retinal Image Translation to Improve Glaucoma Screening With Deep Learning
Purpose: The purpose of this study was to improve automated glaucoma detection by utilizing generative adversarial networks (GANs) to translate...
January 18, 2026
Setting the Target IOP
There is little evidence to support any particular algorithm to set the target IOP" (...) Target IOP should be reviewed at each monitoring visit...
December 20, 2025
The future of glaucoma management and policy implication
Thanks to many recent well-conducted population-based studies in Europe we now have a much better understanding of glaucoma prevalence and...
December 20, 2025
TRPV4 and Glaucoma
The TRPV4 ion channel plays a role in several retinal functions. TRPV4 may participate in the response to mechanical and osmotic stimuli within the...
December 16, 2025
Crowd-sourced glaucoma study. Definition of glaucoma for research by a large group of global expert evaluators
Purpose: The Crowd Sourced Glaucoma Study (CSGS) sought to derive an objective definition of glaucoma for research based on combined assessments by...
December 16, 2025
Peripapillary scleral stiffening increase optic nerve head shear deformation in porcine eyes during IOP elevation
Purpose: Computational models predicted that peripapillary sclera (PPS) stiffening may reduce intraocular pressure (IOP) induced stresses and...
December 16, 2025
In markedly unilateral glaucoma, always rule out secondary causes before labelling the disease as primary
Primary open-angle glaucoma is generally bilateral, even if asymmetric. Therefore, a strongly unilateral presentation should raise suspicion for...
December 16, 2025
Six-Year Rate of Visual Field Progression in the Laser in Glaucoma and Ocular Hypertension Trial
Purpose: To compare the 6-year rate of visual field (VF) progression in the 2 arms of the Laser in Ocular Hypertension and Glaucoma Trial (LiGHT),...
December 16, 2025
Childhood glaucoma
Initial surgery is indicated in nearly all cases of primary congenital glaucoma. Medical treatment is usually neither effective nor practicable in...
November 20, 2025
Cost-effectiveness of glaucoma care and glaucoma screening
Although direct evidence on the cost-effectiveness of glaucoma treatment is limited, hypotensive therapy remains a clinically justified approach...
November 20, 2025
Biomechanical Relationships Between the Aqueous Veins and Perilimbal Sclera During Intraocular Pressure Regulation
Purpose: A major assumption of microinvasive glaucoma surgeries (MIGS) is that effective intraocular pressure (IOP) reduction can be achieved by...
November 18, 2025
Quality of care in patients with newly diagnosed glaucoma
Importance: Various communities continue to experience relatively high rates of glaucoma-related visual impairment and blindness. Identifying...
November 17, 2025
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Real-world data landscape for glaucoma in Europe: a questionnaire-based analysis of resources among European Glaucoma Society members
Background/aims : To investigate the landscape to support Europe-wide collaborative real-world data (RWD) collection, exploring whether required...
November 17, 2025
Do not change glaucoma therapy in a progressing patient until you can exclude non-adherence to the prescribed therapy as the reason for progression
Science behind the tip: Glaucoma management is challenging and one of the most important tasks is keeping your glaucoma patient adherent to the...
November 17, 2025
Prevalence of Glaucoma in Europe and Projections to 2050: Findings from the European Eye Epidemiology Consortium
Purpose: To provide updated glaucoma prevalence estimates and to quantify the current and future burden of disease in Europe. Design: Two-stage,...
October 19, 2025
F4H5 Alleviates Increased Outflow Resistance Induced by Emulsified Silicone Oil In Vitro
Purpose: The purpose of this study was to investigate the effect of emulsified silicone oil on trabecular outflow resistance using an in vitro...
October 19, 2025