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F4H5 Alleviates Increased Outflow Resistance Induced by Emulsified Silicone Oil In Vitro
Purpose: The purpose of this study was to investigate the effect of emulsified silicone oil on...
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The scleral spur
The scleral spur is a ring-shaped structure, primarily collagen with 5% elastin (1), providing...
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Neuroprotection in Glaucoma: Investigational, Complementary to IOP-Lowering
Tip: Neuroprotection in glaucoma is investigational and may be considered only as an adjunct,...
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Evaluating High Intraocular Pressure Criteria for Failure in Glaucoma Surgery: Impact on Estimated Success and Visual Field Rates
Purpose: Review high intraocular pressure (IOP) thresholds used as failure criteria in glaucoma...
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Gonioscopy is always essential
Angle closure is defined by iridotrabecular contact of ≥180° (1) and the presence or development...
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Association of Blood Pressure and Retinal Nerve Fiber Layer Rates of Thinning in Patients with Moderate to Advanced Glaucoma
Objective: To investigate the influence of baseline blood pressure (BP) on retinal nerve fiber...
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Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use - A Prospective Study
Purpose: To investigate the correlations between aqueous humor total antioxidant capacity (TAC)...
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Care Delivery
SIG Corner Editor: Hana Abouzeid Chair: Anton B. Hommer Co-chair: Gabor Hollo Update on ongoing...
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Comparative Study of Early Safety and Effectiveness Outcomes of the PreserFlo MicroShunt with and without an Intraluminal Suture Stent
Objective: To assess the early safety and effectiveness outcomes of the PreserFlo MicroShunt with...
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Iris Crypts Could Reduce the Chance of Angle Closure: A Computational Biomechanics Study Derived From Clinical and Human Iris Data
Purpose: To investigate the effect of crypts during pupil constriction and dilation on the...
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Glaucoma drainage devices - Is the Paul glaucoma implant suitable for children with glaucoma?
Only a few studies exist on the Paul glaucoma device in children with glaucoma. Compared to Ahmed...
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Comparison of Methods to Deliver Mitomycin C in Trabeculectomy Surgery: a Systematic Review and Meta-analysis
Purpose: Compare different methods to deliver Mitomycin C (MMC) in trabeculectomy surgery....
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Laser trabeculoplasty
ALT and SLT have the same IOP-lowering efficacy. Laser trabeculoplasty is initially effective in 80 to 85% of treated eyes with a mean IOP...
February 19, 2026
Choosing wisely / Things to avoid
Do not use MIGS on a rapidly worsening patient. MIGS are mostly used to offer the opportunity to mildly lower the IOP and decrease medications in...
February 19, 2026
Start with monotherapy
The greatest reduction of IOP is obtained with PGAs, followed by non-selective β-blockers, Rho-kinase inhibitors, alpha-adrenergic agonists,...
January 21, 2026
Intraocular pressure and corneal thickness
Ophthalmologists should be aware that tonometry readings may substantially underestimate IOP in patients treated for the correction of myopia with...
January 21, 2026
Setting the Target IOP
There is little evidence to support any particular algorithm to set the target IOP" (...) Target IOP should be reviewed at each monitoring visit...
December 20, 2025
The future of glaucoma management and policy implication
Thanks to many recent well-conducted population-based studies in Europe we now have a much better understanding of glaucoma prevalence and...
December 20, 2025
Childhood glaucoma
Initial surgery is indicated in nearly all cases of primary congenital glaucoma. Medical treatment is usually neither effective nor practicable in...
November 20, 2025
Cost-effectiveness of glaucoma care and glaucoma screening
Although direct evidence on the cost-effectiveness of glaucoma treatment is limited, hypotensive therapy remains a clinically justified approach...
November 20, 2025
Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...
September 01, 2021
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Early Lens Extraction for Primary Angle Closure Glaucoma – Implications of the EAGLE Trial
Pearls Manager: Hari Jayaram Patients newly diagnosed with Primary Angle Closure Glaucoma without advanced damage or Primary Angle Closure with IOP...
July 30, 2021
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Drops or SLT as First Line Treatment? – Implications of the LiGHT Trial
Pearls Manager: Hari Jayaram Newly diagnosed patients with Ocular Hypertension or Open Angle Glaucoma were randomised to one of two treatment...
June 30, 2021
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Observation or Laser Peripheral Iridotomy? – Implications of the ZAP Trial
Pearls Manager: Hari Jayaram The ZAP study was a single-centre randomised clinical trial performed in China to compare Laser Peripheral Iridotomy...
May 30, 2021
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Observation or Treatment? – Implications of the Ocular Hypertension Treatment Study
Pearls Manager: Hari Jayaram The OHTS was a multicentre randomised clinical trial designed to study the effect of topical ocular hypotensive...
April 30, 2021
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Patient Co-operation is Essential to Achieve IOP-Lowering and Successful Outcomes
Pearls Manager: Hari Jayaram Adherence and continued usage of (“persistence”) prescribed glaucoma management is necessary to achieve sustained IOP...
March 30, 2021
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Glaucoma associated with retinal detachment
Pearls Manager: Andrew Tatham Retinal detachment is usually associated with reduction of intraocular pressure (IOP) but long standing retinal...
March 20, 2021
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Visual Field Progression
Pearls Manager: Andrew Tatham Visual field progression analyses may be event or trend-based. Trend analyses quantify rate of progression, usually...
February 21, 2021
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Anxiety associated with glaucoma
Pearls Manager: Andrew Tatham Diagnosis with glaucoma is a moment of anxiety for patients that can be mitigated by provision of timely support and...
February 20, 2021
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Anterior chamber angle imaging cannot replace gonioscopy
Pearls Manager: Andrew Tatham Anterior chamber angle imaging devices can be useful to identify the iris configuration of a narrow angle, to assess...
January 30, 2021
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Glaucoma associated with retinal detachment
Pearls Manager: Andrew Tatham Retinal detachment is usually associated with reduction of intraocular pressure (IOP) but long standing retinal...
January 30, 2021
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Optical coherence tomography for glaucoma diagnosis
Pearls Manager: Andrew Tatham Optical coherence tomography (OCT) on its own does not provide a clinical diagnosis of glaucoma, just a statistical...
December 30, 2020
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Minimally invasive and micro incisional glaucoma surgery
Pearls Manager: Andrew Tatham Surgical procedures that entail less tissue manipulation with the expectation of a better safety profile and quicker...
November 30, 2020
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Malignant glaucoma
Pearls Manager: Andrew Tatham Malignant glaucoma or aqueous misdirection is a rare type of secondary angle closure glaucoma most commonly...
October 20, 2020
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Optimising eye drop instillation
Pearls Manager: Andrew Tatham When two eye drops are instilled 30 seconds apart, almost 50% of the first drug will be washed out. It is recommended...
September 30, 2020
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The Collaborative Normal Tension Glaucoma Study (CNTGS)
Pearls Manager: Andrew Tatham The CNTGS compared treatment versus no treatment in patients with normal tension glaucoma who had verified...
July 30, 2020
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Wound healing is one of the main determinants of long-term intraocular pressure control after filtering surgery
Pearls Manager: Andrew Tatham Risk factors for conjunctival scarring include young age, African ancestry, inflammatory eye disease, long-term...
June 18, 2020