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Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization
Purpose: Glaucoma is the primary cause of permanent vision loss worldwide. However, the...
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Quality of Life and Primary Open-Angle Glaucoma in the Ocular Hypertension Treatment Study
Importance: If preperimetric glaucoma reduces patient-reported vision-related quality of life...
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Fatal beauty: which cosmetics are your glaucoma patients using?
Colorism refers to the difference in social treatment between light-skinned and dark-skinned...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Consider trabeculectomy as initial treatment for newly diagnosed advanced primary open angle glaucoma (POAG)
IOP control is of uttermost importance in advanced glaucoma to prevent blindness. The EGS guidelines recommend IOP in the low teens, e.g. 10-12mmHg...
October 31, 2021
In vivo imaging of the Schlemm's Canal and the response to Selective laser trabeculoplasty
Author(s): Toshit Varshney (1), Kishan Azmira (1), Shikha Gupta (1), Karthikeyan Mahalingam (1), Abhishek Singh (1), Dewang Angmo (1), Viney Gupta...
October 31, 2021
Preservation of vision after CaMKII-mediated protection of retinal ganglion cells
Author(s): 1 Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. 2 Department of Neuroscience, Yale...
October 31, 2021
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Take a look at the deviation maps when assessing structural change in glaucoma
The structural analysis of the thickness of peripapillary retinal nerve fiber layer (pRNFL) and the inner layers of the posterior pole with optical...
September 30, 2021
Long-Term Outcomes of Selective Laser Trabeculoplasty for Open-Angle Glaucoma in the Caribbean
Author(s): Tony Realini (1), Hazel Shillingford-Ricketts (2), Darra Burt (3), Goundappa K Balasubramani (4) 1 West Virginia University Eye...
September 30, 2021
Agonist of growth hormone-releasing hormone enhances retinal ganglion cell protection induced by macrophages after optic nerve injury
Author(s): Ling-Ping Cen (1), Tsz Kin Ng (1,2,3), Jia-Jian Liang (1), Ciyan Xu (1), Xi Zhuang (1), Yu-Fen Liu (1,2), Shao-Lang Chen (1), Yanxuan Xu...
September 30, 2021
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The glaucoma intensive treatment study: interim results from an ongoing longitudinal randomized clinical trial
Author(s): Boel Bengtsson (1), Christina Lindén (2), Anders Heijl (1), Sabina Andersson-Geimer (1), Johan Aspberg (1), Gauti Jóhannesson (2,3) 1...
September 30, 2021
Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma filtration surgery (1). Cataract surgery causes anterior...
September 01, 2021
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In patients with unilateral angle recession glaucoma, the non-traumatized fellow eye should also be periodically checked
Angle recession (AR) is a common complication after a blunt ocular trauma, and it is related to a higher risk of developing late-onset glaucoma...
July 31, 2021
Gonioscopy-assisted transluminal trabeculotomy (GATT) for myocilin juvenile glaucoma
Author(s): Erin A Boese (1), Wallace L M Alward (2), John H Fingert (2) Department Ophthalmology and Visual Sciences, Carver College of Medicine,...
July 31, 2021
A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure
Author(s): Guorong Li (1), Astrid F Nottebaum (2), Mitchell Brigell (3), Iris D Navarro (1), Ute Ipe (2), Sarthak Mishra (2), Maria Gomez-Caraballo...
July 31, 2021
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Early Lens Extraction for Primary Angle Closure Glaucoma – Implications of the EAGLE Trial
Pearls Manager: Hari Jayaram Patients newly diagnosed with Primary Angle Closure Glaucoma without advanced damage or Primary Angle Closure with IOP...
July 30, 2021
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Consider Charles Bonnet syndrome in glaucoma patients even if visual acuity is still good
Charles Bonnet syndrome (CBS) describes the presence of complex visual hallucinations with retained insight in the unreal nature of the phenomenon...
June 30, 2021
Ab-externo MicroShunt versus Trabeculectomy in Primary Open-Angle Glaucoma: 1-year Results from a 2-year Randomized, Multicenter Study
Author(s): N Douglas Baker (1), Howard S Barnebey (2), Marlene R Moster (3), Michael C Stiles (4), Steven D Vold (5), Anup K Khatana (6), Brian E...
June 30, 2021
Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma
Author(s): Pinkal D Patel (1), Yen-Lin Chen (2), Ramesh B Kasetti (1), Prabhavathi Maddineni (1), William Mayhew (1), J Cameron Millar (1), Dorette...
June 30, 2021
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Improving the Power of Glaucoma Neuroprotection Trials Using Existing Visual Field Data
Author(s): Giovanni Montesano (1), Harry A Quigley (2), David P Crabb (3) 1 City, University of London Optometry and Visual Sciences (G.M.,...
June 30, 2021
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Drops or SLT as First Line Treatment? – Implications of the LiGHT Trial
Pearls Manager: Hari Jayaram Newly diagnosed patients with Ocular Hypertension or Open Angle Glaucoma were randomised to one of two treatment...
June 30, 2021
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Consider focal pressure in case of poor filtration shortly after trabeculectomy
Achieving a good filtration in the early postoperative period after trabeculectomy is associated with the procedure's long-term success (1)....
May 31, 2021
Ten-Year Clinical Outcomes of Acute Primary Angle Closure Randomized to Receive Early Phacoemulsification Versus Laser Peripheral Iridotomy
Author(s): Poemen P Chan (1,2), Fang Y Tang (1), Dexter Y Leung (1,3), Thomas C Lam (1,2), Nafees Baig (1,4,3), Clement C Tham (1,2,5) 1 Department...
May 31, 2021
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
Author(s): Puya Gharahkhani (1), Eric Jorgenson (2), Pirro Hysi (3), Anthony P Khawaja (4,5), Sarah Pendergrass (6) et al. 1 QIMR Berghofer Medical...
May 31, 2021
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Observation or Laser Peripheral Iridotomy? – Implications of the ZAP Trial
Pearls Manager: Hari Jayaram The ZAP study was a single-centre randomised clinical trial performed in China to compare Laser Peripheral Iridotomy...
May 30, 2021
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Ganglion cell-inner plexiform layer examination can help diagnose glaucoma in high myopia
Myopia can be associated with significant structural changes in the eye, including peripapillary atrophy, myopic macular degeneration and the...
April 30, 2021
Quality of Life in Primary Open-Angle Glaucoma and Cataract: An Analysis of VFQ-25 and OSDI from the iStent inject® Pivotal Trial
Author(s): Thomas W Samuelson (1), Inder Paul Singh (2), Blake K Williamson (3), Heather Falvey (4), Won Chan Lee (5), Dawn Odom (6), David...
April 30, 2021
Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye
Author(s): Genetics of Exfoliation Syndrome Partnership For a full list of authors and affiliations please visit...
April 30, 2021
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Observation or Treatment? – Implications of the Ocular Hypertension Treatment Study
Pearls Manager: Hari Jayaram The OHTS was a multicentre randomised clinical trial designed to study the effect of topical ocular hypotensive...
April 30, 2021