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Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization
Purpose: Glaucoma is the primary cause of permanent vision loss worldwide. However, the...
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Quality of Life and Primary Open-Angle Glaucoma in the Ocular Hypertension Treatment Study
Importance: If preperimetric glaucoma reduces patient-reported vision-related quality of life...
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Fatal beauty: which cosmetics are your glaucoma patients using?
Colorism refers to the difference in social treatment between light-skinned and dark-skinned...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Consider using preservative-free topical medication in patients with ocular surface disease
The Science behind the Tip Many glaucoma drops contain a preservative agent to minimise the risk of microbial contamination. Benzalconium chloride,...
November 30, 2013
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Cataract surgery after trabeculectomy increases the risk of bleb failure and this risk is increased if the time between trabeculectomy and cataract surgery is short
The Science behind the Tip Trabeculectomy surgery is a recognised risk factor for the subsequent development of cataract. Phacoemulsification with...
November 30, 2013
Pathogenesis and clinical implications of optic disk hemorrhage in glaucoma
Author(s): Suh MH, Park KH. Department of Ophthalmology, Haeundae Paik Hospital, Busan, Korea; Department of Ophthalmology, Inje University College...
November 30, 2013
Identification of retinal ganglion cell neuroprotection conferred by platelet-derived growth factor through analysis of the mesenchymal stem cell secretome
Author(s): Johnson TV, Dekorver NW, Levasseur VA, Osborne A, Tassoni A, Lorber B, Heller JP, Villasmil R, Bull ND, Martin KR, Tomarev SI 1 Section...
November 30, 2013
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Generic drops can differ from brand drops and it may be necessary to monitor patients more closely after switching
The Science behind the Tip In order to be approved for general use, a generic drug has to show the criterion of essential similarity when compared...
October 31, 2013
Lifetime Risk of Blindness in Open-Angle Glaucoma
Author(s): Peters D, Bengtsson B, Heijl A Department of Ophthalmology, Lund University, Skåne University Hospital, Malmö, Sweden. Electronic...
October 31, 2013
Immune response against ocular tissues after immunization with optic nerve antigens in a model of autoimmuneglaucoma
Author(s): Joachim SC, Reinehr S, Kuehn S, Laspas P, Gramlich OW, Kuehn M, Tischoff I, von Pein HD, Dick HB, Grus FH Experimental Eye Research...
October 31, 2013
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The measurement of retinal nerve fibre thickness is helpful in determining which patients with ocular hypertension will develop glaucoma
The Science behind the Tip In patients with ocular hypertension, moderate to severe retinal nerve fibre layer (RNFL) atrophy at baseline has been...
September 30, 2013
The Ahmed Versus Baerveldt Study: Three-Year Treatment Outcomes
Author(s): Christakis PG, Tsai JC, Kalenak JW, Zurakowski D, Cantor LB, Kammer JA, Ahmed II. Department of Ophthalmology and Vision Sciences,...
September 30, 2013
Onset and Progression of Peripapillary Retinal Nerve Fiber Layer (RNFL) Retardance Changes Occur Earlier than RNFL Thickness Changes in Experimental Glaucoma
Author(s): Fortune B, Burgoyne CF, Cull G, Reynaud J, Wang L. Devers Eye Institute, Legacy Research Institute, 1225 NE 2nd Avenue, 3rd Floor,...
September 30, 2013
Rho-associated kinase inhibitors: A novel glaucoma therapy
Author(s): Inoue T, Tanihara H. Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto, Japan....
July 31, 2013
Ocular Rigidity, Outflow facility, Ocular Pulse Amplitude and Pulsatile Ocular Blood Flow in Open AngleGlaucoma; a manometric study
Author(s): Dastiridou AI, Tsironi EE, Tsilimbaris M, Ginis H, Karyotakis N, Cholevas P, Androudi S, Pallikaris IG. Ophthalmology Department,...
July 31, 2013
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Post-traumatic angle-recession glaucoma is difficult to manage and surgical intervention is often required
The Science behind the Tip Anterior chamber angle recession is the commonest physical sign of previous blunt trauma to the eye. Raised intraocular...
June 30, 2013
Prevalence and Severity of Undetected Manifest Glaucoma: Results from the Early Manifest Glaucoma Trial Screening
Author(s): Heijl A, Bengtsson B, Oskarsdottir SE. Lund University, Department of Clinical Sciences Malmö, Ophthalmology, Skåne University Hospital,...
June 30, 2013
Acetylcholinesterase inhibition promotes retinal vasoprotection and increases ocular blood flow in experimental glaucoma
Author(s): Almasieh M, Macintyre JN, Pouliot M, Casanova C, Vaucher E, Kelly ME, Di Polo A. Department of Pathology and Cell Biology and Groupe de...
June 30, 2013
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The use of Ginkgo biloba may increase the risk of bleeding
The Science behind the Tip Extracts of the leaves of the Asiatic tree Ginkgo biloba (GBE) provide protection against mitochondrial oxidative damage...
May 31, 2013
The eye and the heart
Author(s): Flammer J, Konieczka K, Bruno R M, Virdis A, Flammer A J, Taddei S The vasculature of the eye and the heart share several common...
May 31, 2013
Reduction in Blood Glutathione Levels Occurs Similarly in Patients with Primary-Open Angle or Normal Tension Glaucoma
Author(s): Gherghel D, Mroczkowska S, Qin L Vascular Research Laboratory, Ophthalmic Research Group, Aston University, School of Life and Health...
May 31, 2013
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If surgery is required to control IOP in a patient with nanophthalmos, phacoemulsification with IOL implantation is a good option, but the complication rate is high
The Science behind the Tip Nanophthalmos, small eye-big trouble, is a form of microophthalmos which is not accompanied by other congenital...
April 30, 2013
How Does Glaucoma Look?: Patient Perception of Visual Field Loss
Author(s): Crabb DP, Smith ND, Glen FC, Burton R, Garway-Heath DF Department of Optometry and Visual Science, City University London, London,...
April 30, 2013
Tissue engineering the retinal ganglion cell nerve fiber layer
Author(s): Kador KE, Montero RB, Venugopalan P, Hertz J, Zindell AN, Valenzuela DA, Uddin MS, Lavik EB, Muller KJ, Andreopoulos FM, Goldberg JL...
April 30, 2013
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Indefinite use of cycloplegics can be the last resort when surgery for malignant glaucoma has failed
The Science behind the Tip Malignant glaucoma or aqueous misdirection is a rare but feared complication of anterior segment surgery. It occurs in...
March 31, 2013
Treatment Outcomes in Malignant Glaucoma
Author(s): Dave P, Senthil S, Rao HL, Garudadri CS. L. V. Prasad Eye Institute, Hyderabad, India. PURPOSE: To report treatment outcomes in...
March 31, 2013
Discovery of novel human aquaporin-1 blockers
Author(s): Seeliger D, Zapater C, Krenc D, Haddoub R, Flitsch S, Beitz E, Cerdà J, de Groot BL. Human aquaporin-1 (hAQP1) is a water channel found...
March 31, 2013
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Young men of European ancestry with angle-closure require thorough investigation
The Science behind the Tip Primary angle closure glaucoma is rare in younger white adults, with an estimated age specific prevalence of 0.02% for...
February 28, 2013