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Comparison of Methods to Deliver Mitomycin C in Trabeculectomy Surgery: a Systematic Review and Meta-analysis
Purpose: Compare different methods to deliver Mitomycin C (MMC) in trabeculectomy surgery....
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Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use - A Prospective Study
Purpose: To investigate the correlations between aqueous humor total antioxidant capacity (TAC)...
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Optic Disc Microvasculature Reduction and Visual Field Progression in Primary Open-Angle Glaucoma
Purpose: To investigate the relationship between optic disc vessel density (ODVD) reduction and...
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Consider cotton wool spots as potential triggers for (non-glaucomatous) nerve fibre bundle defects
It may be tempting to make a glaucoma diagnosis in the presence of a nerve fibre bundle defect...
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Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition
Purpose: We tested the hypothesis that a questionnaire-based risk score predicts the prevalence...
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Not every ring scotoma is due to glaucoma
In advanced stages of glaucoma, patients may present with an annular scotoma, also known as ring...
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Relationship between Blood Pressure and Rates of Glaucomatous Visual Field Progression
Purpose: To examine the relationship between systemic arterial blood pressure (BP) and the rate...
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Comparison of Outcomes of Deep Sclerectomy, Canaloplasty, and Viscocanaloplasty: A Multi-Centred Study
Prcis: Deep sclerectomy (DS) and canaloplasty provide better intraocular pressure (IOP) control...
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Macular Oxygen Saturation in Glaucoma Using Retinal Oximetry of Visible Light Optical Coherence Tomography: A Pilot Study
Purpose: A cross-sectional pilot study to compare macular oxygen saturation (sO2) and associated...
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Childhood Glaucoma
SIG Corner Editor: Hana Abouzeid Chair: Esther Hoffmann Co-chair: Zeynep Aktas Childhood glaucoma...
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Avoid premature removal of the intraluminal suture in glaucoma drainage devices to minimize the risk of hypotony
While prolene suture removal is an effective method for reducing IOP at the slit-lamp, removing...
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Biomechanics-Function in Glaucoma: Improved Visual Field Predictions from IOP-Induced Neural Strains
Purpose: (1) To assess whether neural tissue structure and biomechanics could predict functional...
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Successful optic nerve regeneration in the senescent zebrafish despite age-related decline of cell intrinsic and extrinsic response processes
Author(s): Van Houcke J (1), Bollaerts I (1), Geeraerts E (1), Davis B (2), Beckers A (1), Van Hove I (1), Lemmens K (1), De Groef L (3), Moons L...
October 31, 2017
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Glaucoma associated with congenital aniridia is difficult to treat, but tube-shunt drainage devices offer the best results
The Science behind the Tip Congenital aniridia is a rare bilateral developmental disorder which is inherited in an autosomal dominant fashion in...
September 30, 2017
Rates of glaucomatous visual field change after trabeculectomy
Author(s): Baril C (1), Vianna JR (1), Shuba LM (1), Rafuse PE (1), Chauhan BC (1), Nicolela MT (1) 1 Department of Ophthalmology and Visual...
September 30, 2017
Mitochondrial dysfunction in ocular disease: Focus on glaucoma
Author(s): Kamel K (1), Farrell M (2), O'Brien C (3) 1 Institute of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland. 2...
September 30, 2017
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In a young patient with acute congestive angle closure or recurrent angle closure in the presence of a patent laser iridotomy, the underlying cause is usually plateau iris configuration
The Science behind the Tip Plateau iris configuration is characterised by a closed anterior chamber angle in association with a flat iris plane and...
July 31, 2017
Risk Factors for Rapid Glaucoma Disease Progression
Author(s): Chan TCW (1), Bala C (2), Siu A (3), Wan F (3), White A (4) 1 University of Sydney, Sydney, Australia. 2 Macquarie University, Sydney,...
July 31, 2017
Interleukin-6 Deficiency Attenuates Retinal Ganglion Cell Axonopathy and Glaucoma-Related Vision Loss
Author(s): 1 Neuroscience Graduate Program, Vanderbilt UniversityNashville, TN, United States. 2 Department of Ophthalmology and Visual Sciences,...
July 31, 2017
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The chronic use of prostaglandin analogues may lead to a modest underestimation of IOP when measured by Goldmann applanation tonometry
The Science behind the Tip Corneal hysteresis is a biomechanical property of the cornea relating to its elasticity. The measurement of corneal...
June 30, 2017
Mitochondrial dysfunction in ocular disease: Focus on glaucoma
Author(s): Kamel K (1), Farrell M (2), O'Brien C (3) 1 Institute of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland. 2...
June 30, 2017
Regulation of intraocular pressure by microRNA cluster miR-143/145
Author(s): Li X (1,2), Zhao F (3,4), Xin M (5), Li G (6), Luna C (6), Li G (1), Zhou Q (4), He Y (2), Yu B (4), Olson E (7), Gonzalez P (6), Wang S...
June 30, 2017
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In a patient with glaucoma who has unexplained hair loss, stop topical beta-blocker treatment
The Science behind the Tip Beta adrenergic receptor blocking eye drops are often used to reduce the intraocular pressure. Because of absorption...
May 31, 2017
Neuroprotection for glaucoma: Requirements for clinical translation
Author(s): Levin LA (1), Crowe ME (2), Quigley HA (3); Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants 1...
May 31, 2017
Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma
Author(s): Zhu W (1), Jain A (2), Gramlich OW (3), Tucker BA (3), Sheffield VC (4), Kuehn MH (1) 1 Department of Ophthalmology and Visual Sciences,...
May 31, 2017
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Patients with normal tension glaucoma who develop a branch retinal vein occlusion should be monitored with greater care
The Science behind the Tip If a branch retinal vein occlusion (BRVO) occurs in a patient with normal tension glaucoma, it tends to occur in the eye...
April 30, 2017
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Visual function may improve after trabeculectomy in some adults with moderately advanced glaucoma
The Science behind the Tip We were taught that visual field loss from glaucoma is irreversible and that our interventions could at best, preserve...
March 31, 2017
The challenge of regenerative therapies for the optic nerve in glaucoma
Author(s): Calkins DJ (1), Pekny M (2), Cooper ML (3), Benowitz L (4); Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration...
March 31, 2017
The pressure-induced deformation response of the human lamina cribrosa: Analysis of regional variations
Author(s): Midgett DE (1), Pease ME (2), Jefferys JL (2), Patel M (3), Franck C (3), Quigley HA (2), Nguyen TD (4) 1 Department of Mechanical...
March 31, 2017
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The regular (and sometimes clandestine) application of periocular corticosteroid cream can induce glaucoma in susceptible individuals
The Science behind the Tip Steroid-induced ocular hypertension and glaucoma is typically associated with topical steroid therapy and presents with...
February 28, 2017
Posner-Schlossman Syndrome
Author(s): Megaw R (1), Agarwal PK (2) 1 Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of...
February 28, 2017
New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics
Author(s): Springelkamp H (1,2), Iglesias AI, Mishra A (3,4), Höhn R (5,6), Wojciechowski R, Khawaja AP (7), Nag A (8), Wang YX (9,10), Wang JJ...
February 28, 2017
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In patients with primary angle-closure glaucoma and primary angle closure with high intraocular pressure (IOP), there is a good evidence to support the use of clear lens extraction with intraocular lens implantation as initial treatment
The Science behind the Tip The standard treatment for primary angle-closure glaucoma (PACG) is laser peripheral iridotomy (PI) to open the drainage...
January 31, 2017
Glaucoma Risk Alleles in the Ocular Hypertension Treatment Study
Author(s): Scheetz TE (1), Faga B (1), Ortega L (2), Roos BR (1), Gordon MO (3), Kass MA (3), Wang K (4), Fingert JH (5) 1 Department Ophthalmology...
January 31, 2017
Lamina cribrosa in glaucoma
Author(s): Downs JC (1), Girkin CA 1 Department of Ophthalmology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA....
January 31, 2017
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Patients with neovascular glaucoma should be referred to a general physician as management of their underlying systemic disease should increase their life expectancy
The Science behind the Tip Most patients with neovascular glaucoma have retinal ischaemia secondary to either proliferative diabetic retinopathy,...
December 31, 2016
New classes of glaucoma medications
Author(s): Schehlein EM (1), Novack GD, Robin AL 1 a University of Maryland School of Medicine, Department of Ophthalmology and Visual Sciences,...
December 31, 2016