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Balancing Glaucoma Care: Tackling Overdiagnosis and Overtreatment to Preserve Patient Quality of Life
The Science behind the Tip In contrast to underdiagnosis, which has been described in...
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Peripapillary Retinoschisis in Glaucoma: A Systematic Review
PURPOSE: The frequent use of optical coherence tomography increased the detection of...
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Evaluating Primary Treatment for People with Advanced Glaucoma: Five-Year Results of the Treatment of Advanced Glaucoma Study
Purpose: To determine whether primary trabeculectomy or medical treatment produces better...
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Activation of the ROCK/MYLK Pathway Affects Complex Molecular and Morphological Changes of the Trabecular Meshwork Associated With Ocular Hypertension
Purpose: The Rho-associated protein kinase and myosin light chain kinase (ROCK/MYLK) pathway...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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What have we learned about exfoliation syndrome since its discovery by John Lindberg 100 years ago?
Author(s): Nazarali S (1), Damji F (2), Damji KF (3) 1 Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. 2 School of Kinesiology,...
May 31, 2018
The coma in glaucoma: Retinal ganglion cell dysfunction and recovery
Author(s): Fry LE (1), Fahy E (2), Chrysostomou V (3), Hui F (2), Tang J (2), van Wijngaarden P (2), Petrou S (4), Crowston JG (5) 1 Centre for Eye...
May 31, 2018
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In a patient with pigment dispersion syndrome, the most significant ocular risk factor for conversion to glaucoma is an IOP above 21mmHg on presentation
The Science behind the Tip Pigment dispersion syndrome tends to occur in young myopic white men. There are genetic factors that underly the risk...
April 30, 2018
Twenty-year outcomes in patients with newly diagnosed glaucoma: mortality and visual function
Author(s): King C (1), Sherwin JC (1), Ratnarajan G (2), Salmon JF (1) 1 Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust,...
April 30, 2018
Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma
Author(s): Huard DJE (1), Crowley VM (2), Du Y (3), Cordova RA (4), Sun Z (4), Tomlin MO (1), Dickey CA (4), Koren J 3rd (4), Blair L (4), Fu H...
April 30, 2018
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Validated prediction models are helpful to determine the risk of an individual with ocular hypertension developing chronic glaucoma
The Science behind the Tip Raised intraocular pressure (IOP) is an important risk factor for the development of glaucoma and can be modified with...
March 31, 2018
Physical exercise and glaucoma: a review on the roles of physical exercise on intraocular pressure control, ocular blood flow regulation, neuroprotection and glaucoma-related mental health
Author(s): Zhu MM (1), Lai JSM (1), Choy BNK (1), Shum JWH (1), Lo ACY (1), Ng ALK (1), Chan JCH (1), So KF (1,2,3,4) 1 Department of...
March 31, 2018
Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma
Author(s): Gharahkhani P (1), Burdon KP (2), Cooke Bailey JN (3), Hewitt AW (2), Law MH (4), Pasquale LR (5), (6), Kang JH (6), Haines JL (3),...
March 31, 2018
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Measuring the intraocular pressure (IOP) not only in sitting, but also in supine position, may help to identify the 24-hour IOP characteristics of your glaucoma patient
The Science behind the Tip It is well known that each patient has an individual circadian IOP pattern. Studies have shown that up to two thirds of...
February 28, 2018
The Iridocorneal Endothelial Syndrome
Author(s): Silva L (1), Najafi A (2), Suwan Y (3), Teekhasaenee C (4), Ritch R (2) 1 Einhorn Clinical Research Center, The New York Eye and Ear...
February 28, 2018
Anesthetic Preconditioning as Endogenous Neuroprotection in Glaucoma
Author(s): Chou TH (1), Musada GR (2), Romano GL (3), Bolton E (4), Porciatti V (5) 1 Bascom Palmer Eye Institute, University of Miami Miller...
February 28, 2018
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Treatment of ischaemic central retinal vein occlusion with prophylactic anti-VEGF injections reduces the risk of neovascular glaucoma, but careful long-term monitoring for ocular new vessels remains essential
The Science behind the Tip Approximately 20% of central retinal vein occlusions (CRVO) are ischaemic and of those, 45% develop neovascular...
January 31, 2018
Detecting Visual Field Progression
Author(s): Aref AA (1), Budenz DL (2) 1 Illinois Eye & Ear Infirmary, University of Illinois at Chicago College of Medicine, Chicago, Illinois....
January 31, 2018
ASK1 in neurodegeneration
Author(s): Guo X (1), Namekata K (2), Kimura A (2), Harada C (2), Harada T (2) 1 Visual Research Project, Tokyo Metropolitan Institute of Medical...
January 31, 2018
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OCT measurement of the retinal nerve fibre layer is useful for detecting progression in early glaucoma
The Science behind the Tip Both visual field testing and optical coherence tomography (OCT) measurements can be used to detect glaucomatous...
December 31, 2017
Multiple Temporal Lamina Cribrosa Defects in Myopic Eyes with Glaucoma and Their Association with Visual Field Defects
Author(s): Sawada Y (1), Araie M (2), Ishikawa M (3), Yoshitomi T (3) 1 Department of Ophthalmology, Akita University Graduate School of Medicine,...
December 31, 2017
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Bleb encapsulation after trabeculectomy can be successfully treated by using aqueous suppressant treatment for a short period
The Science behind the Tip Bleb encapsulation may occur 2 to 6 weeks after trabeculectomy, when an elevated, tense, dome-shaped bleb develops with...
November 30, 2017
Rates of Local Retinal Nerve Fiber Layer Thinning before and after Disc Hemorrhage in Glaucoma
Author(s): Akagi T (1), Zangwill LM (2), Saunders LJ (2), Yarmohammadi A (2), Manalastas PIC (2), Suh MH (3), Girkin CA (4), Liebmann JM (5),...
November 30, 2017
Retinal Astrocytes and GABAergic Wide-Field Amacrine Cells Express PDGFRα: Connection to Retinal Ganglion Cell Neuroprotection by PDGF-AA
Author(s): Takahama S (1), Adetunji MO (1), Zhao T (2), Chen S2, Li W (2), Tomarev SI (1) 1 Section on Retinal Ganglion Cell Biology, Laboratory of...
November 30, 2017
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A patient who presents with raised intraocular pressure or glaucoma and distended episcleral veins in one eye needs to be investigated for a spontaneous carotid – cavernous fistula
The Science behind the Tip A carotid – cavernous sinus fistula is an abnormal vascular communication between the carotid artery system and the...
October 31, 2017
Peptides of the variable IgG domain as potential biomarker candidates in primary open-angle glaucoma (POAG)
Author(s): Schmelter C (1), Perumal N (1), Funke S (1), Bell K (1), Pfeiffer N (1), Grus FH (1) 1 Department of Experimental and Translational...
October 31, 2017
Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis
Author(s): Aschard H (1), Kang JH (2), Iglesias AI (3), Hysi P (4), Cooke Bailey JN (5,6), Khawaja AP (7), Allingham RR (8), Ashley-Koch A (9), Lee...
October 31, 2017
Successful optic nerve regeneration in the senescent zebrafish despite age-related decline of cell intrinsic and extrinsic response processes
Author(s): Van Houcke J (1), Bollaerts I (1), Geeraerts E (1), Davis B (2), Beckers A (1), Van Hove I (1), Lemmens K (1), De Groef L (3), Moons L...
October 31, 2017
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Glaucoma associated with congenital aniridia is difficult to treat, but tube-shunt drainage devices offer the best results
The Science behind the Tip Congenital aniridia is a rare bilateral developmental disorder which is inherited in an autosomal dominant fashion in...
September 30, 2017
Rates of glaucomatous visual field change after trabeculectomy
Author(s): Baril C (1), Vianna JR (1), Shuba LM (1), Rafuse PE (1), Chauhan BC (1), Nicolela MT (1) 1 Department of Ophthalmology and Visual...
September 30, 2017