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Balancing Glaucoma Care: Tackling Overdiagnosis and Overtreatment to Preserve Patient Quality of Life
The Science behind the Tip In contrast to underdiagnosis, which has been described in...
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Peripapillary Retinoschisis in Glaucoma: A Systematic Review
PURPOSE: The frequent use of optical coherence tomography increased the detection of...
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Evaluating Primary Treatment for People with Advanced Glaucoma: Five-Year Results of the Treatment of Advanced Glaucoma Study
Purpose: To determine whether primary trabeculectomy or medical treatment produces better...
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Activation of the ROCK/MYLK Pathway Affects Complex Molecular and Morphological Changes of the Trabecular Meshwork Associated With Ocular Hypertension
Purpose: The Rho-associated protein kinase and myosin light chain kinase (ROCK/MYLK) pathway...
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The relationship between multiple deprivation and severity of glaucoma at diagnosis
BACKGROUND: Socioeconomic deprivation is associated with higher odds of chronic diseases, with...
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Angle Closure SIG
SIG Corner Editor: Hana Abouzeid Chair: John Thygesen Co-chair: Gus Gazzard The goal of this SIG...
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Placebo effect and its determinants in ocular hypotensive therapy: meta-analysis and multiple meta-regression analysis
Author(s): Sooyeon Choe (1), Young Kook Kim (2), Woosuk Chung (3), Donghyun Ko (3), Marvin Lee...
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Be aware of the potential influence of the vitreoretinal interface when interpreting OCT images of the retinal nerve fiber layer (RNFL) in glaucoma patients
Vitreous traction can cause artifacts that may obscure RNFL thinning, potentially leading to...
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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank
Author(s): Oana A Zeleznik ° (1,2), Jae H Kang ° (3,4), Jessica Lasky-Su (3,4), A Heather...
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Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Author(s): Mário Lima-Fontes (1), Ana Faria-Pereira (1), Mariana Leuzinger-Dias (1), Marta Inês...
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Oral acetazolamide (Diamox) is known to lower intraocular pressure, but it can very rarely cause acute bilateral angle closure with severely elevated intraocular pressure
The mechanism is thought to be an idiosyncratic reaction to sulphonamides, similar to that which...
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Cataract Surgery in Patients with Functioning Glaucoma Filtration Surgery
The accelerated development of cataract is frequently seen in the years following glaucoma...
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Discovery and Functional Annotation of SIX6 Variants in Primary Open-Angle Glaucoma
Author(s): Ulmer Carnes M(1), Liu YP(2), Allingham RR(3), Whigham BT(3), Havens S(3), Garrett ME(1), Qiao C(4); NEIGHBORHOOD Consortium...
June 30, 2014
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Dietary supplementation and glaucoma
The Science behind the Tip Dietary supplements belong to the broad group of complementary and alternative medicine (CAM). A recent survey in Canada...
May 31, 2014
Effect of Focal Lamina Cribrosa Defect on Glaucomatous Visual Field Progression
Author(s): Faridi OS(1), Park SC(2), Kabadi R(3), Su D(1), De Moraes CG(4), Liebmann JM(4), Ritch R(5) 1 Moise and Chella Safra Advanced Ocular...
May 31, 2014
MMPs in the neuroretina and optic nerve: modulators of glaucoma pathogenesis and repair?
Author(s): De Groef L(1), Van Hove I, Dekeyster E, Stalmans I, Moons L. 1 Laboratory of Neural Circuit Development and Regeneration, Animal...
May 31, 2014
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Patients with pigmentary glaucoma respond well to laser trabeculoplasty, but steps must be taken to reduce the risk of the IOP spike that may occur immediately after the laser treatment
The Science behind the Tip Argon or selective laser trabeculoplasty (LT) is an established therapeutic option in the treatment of patients with...
April 30, 2014
Intraocular pressure fluctuation and glaucoma progression: what do we know?
Author(s): Leidl MC(1), Choi CJ, Syed ZA, Melki SA. 1 Nassau University Medical Center, East Meadow, New York, USA. While mean intraocular pressure...
April 30, 2014
γ-Synuclein Antibodies Have Neuroprotective Potential on Neuroretinal Cells via Proteins of the Mitochondrial Apoptosis Pathway
Author(s): Wilding C, Bell K, Beck S, Funke S, Pfeiffer N, Grus FH. Experimental Ophthalmology, Department of Ophthalmology, Medical Center of the...
April 30, 2014
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It is important that glaucoma patients at risk of end-of-life visual impairment should be identified and treated accordingly
The Science behind the Tip The ultimate outcome measure of glaucoma treatment is visual impairment and blindness at the time of death. Based on a...
March 31, 2014
The Potential Association Between Postmenopausal Hormone Use and Primary Open-Angle Glaucoma
Author(s): Newman-Casey PA(1), Talwar N(1), Nan B(2), Musch DC(3), Pasquale LR(4), Stein JD(5). 1 Department of Ophthalmology and Visual Sciences,...
March 31, 2014
Mitochondrial DNA Variant Discovery in Normal-Tension Glaucoma Patients by Next-Generation Sequencing
Author(s): Jeoung JW(1), Seong MW, Park SS, Kim DM, Kim SH, Park KH. 1 Department of Ophthalmology, Seoul National University Hospital, Seoul,...
March 31, 2014
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Perimetry should be undertaken soon after phacoemulsification and multifocal IOL implantation in patients with glaucoma, in order to establish new baseline parameters
The Science behind the Tip To determine change in visual function in patients with glaucoma, regular visual field testing is undertaken using...
February 28, 2014
Emerging novel roles of neuropeptide Y in the retina: From neuromodulation to neuroprotection
Author(s): Santos-Carvalho A (1), Alvaro AR (2), Martins J (3), Ambrósio AF (4), Cavadas C (5) Neuropeptide Y (NPY) and NPY receptors are widely...
February 28, 2014
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The early diagnosis of glaucoma and early detection of glaucoma progression should be enhanced by the use of spectral domain OCT measurement of the neuro retinal rim
The Science behind the Tip Recent studies using spectral domain ocular coherence tomography (SD OCT) measurement of the optic disc margin show that...
January 31, 2014
The 5-Year Incidence of Bleb-Related Infection and Its Risk Factors after Filtering Surgeries with Adjunctive Mitomycin C: Collaborative Bleb-Related Infection Incidence and Treatment Study 2
Author(s): Yamamoto T (1), Sawada A (2), Mayama C (3), Araie M (3), Ohkubo S (4), Sugiyama K4, Kuwayama Y (5); The Collaborative Bleb-Related...
January 31, 2014
Relationship between Preferred Sleeping Position and Asymmetric Visual-field Loss in Open-angle Glaucoma Patients
Author(s): Kim KN(1), Jeoung JW(2), Park KH(3), Kim DM(4), Ritch R(5) 1 Department of Ophthalmology, Chungnam National University Hospital,...
January 31, 2014
Regulation of Plasticity and Fibrogenic Activity of Trabecular Meshwork Cells by Rho GTPase Signaling
Author(s): Pattabiraman PP, Maddala R, Rao PV. Department of Ophthalmology, Duke University School of Medicine, Durham, NC, 27710. Glaucoma, a...
January 31, 2014
Does optic nerve head surface topography change prior to loss of retinal nerve fiber layer thickness: a test of the site of injury hypothesis in experimental glaucoma
Author(s): Fortune B, Reynaud J, Wang L, Burgoyne CF. Discoveries in Sight Research Laboratories, Devers Eye Institute, and Legacy Research...
December 31, 2013
Anti-Connective Tissue Growth Factor Antibody Treatment Reduces Extracellular Matrix production in Trabecular Meshwork and Lamina Cribrosa cells
Author(s): Wallace DM, Clark AF, Lipson K, Andrews D, Crean J, O'Brien CJ. PURPOSE: We have previously demonstrated elevated levels of Connective...
December 31, 2013
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Consider using preservative-free topical medication in patients with ocular surface disease
The Science behind the Tip Many glaucoma drops contain a preservative agent to minimise the risk of microbial contamination. Benzalconium chloride,...
November 30, 2013
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Cataract surgery after trabeculectomy increases the risk of bleb failure and this risk is increased if the time between trabeculectomy and cataract surgery is short
The Science behind the Tip Trabeculectomy surgery is a recognised risk factor for the subsequent development of cataract. Phacoemulsification with...
November 30, 2013
Pathogenesis and clinical implications of optic disk hemorrhage in glaucoma
Author(s): Suh MH, Park KH. Department of Ophthalmology, Haeundae Paik Hospital, Busan, Korea; Department of Ophthalmology, Inje University College...
November 30, 2013
Identification of retinal ganglion cell neuroprotection conferred by platelet-derived growth factor through analysis of the mesenchymal stem cell secretome
Author(s): Johnson TV, Dekorver NW, Levasseur VA, Osborne A, Tassoni A, Lorber B, Heller JP, Villasmil R, Bull ND, Martin KR, Tomarev SI 1 Section...
November 30, 2013
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Generic drops can differ from brand drops and it may be necessary to monitor patients more closely after switching
The Science behind the Tip In order to be approved for general use, a generic drug has to show the criterion of essential similarity when compared...
October 31, 2013
Lifetime Risk of Blindness in Open-Angle Glaucoma
Author(s): Peters D, Bengtsson B, Heijl A Department of Ophthalmology, Lund University, Skåne University Hospital, Malmö, Sweden. Electronic...
October 31, 2013
Immune response against ocular tissues after immunization with optic nerve antigens in a model of autoimmuneglaucoma
Author(s): Joachim SC, Reinehr S, Kuehn S, Laspas P, Gramlich OW, Kuehn M, Tischoff I, von Pein HD, Dick HB, Grus FH Experimental Eye Research...
October 31, 2013