Local toxicity of topical treatment: the role of preservatives

Therapeutic options to reduce OSD include preservative-free or BAC-free medication, decreasing the number of eye drops (e.g., by using fixed combinations), treating the ocular surface with unpreserved tear substitutes, and performing earlier laser or surgery. Regarding OSD, several factors have to be considered, like the active compound, the specific preservative, and other excipients, the ability of the patient to use single-dose preparations, and the patient’s ocular surface.

EGS Guidelines, 6th Edition, Pages 179

Pearls Manager: Nestor Ventura-Abreu